Abstract: The VLE data for salt-containing binary systems of ethanol／NH_4NO_3 and water/NH_4NO_3 were determined,and were correlated in order to get optimal binary parameters in NRTL model.It is proposed that the titration analysis-gas chromatographic analysis combination method can be used to determine the components in liquid phase for multicomponent salt-containing systems.Salt-containing VLE data for the temary systems of methanol／water／NH_4NO_3, ethanol/water/NH_4NO_3,and for the quaternary system of methanol/ethanol/water／NH_4NO_3 were detenrmined.The optimal binary parameters were used to predict the VLE data for the above-mentioned multicomponent salt-containing systems by Salt-Containing Local Composition Model,and the experimental VLE data were compared with the predicted results.The results shows that the VLE data agreed well with predicted data,and the SaltContaining Local Composition Model was suitable for predicting the VLE of salt-containing quaternarysystems.