Abstract: The construction Of evaluation parameter set is the prerequisite of systematic evaluation. According to the requirement in bioseparation process, an evaluation parameter set is put forward which consists of parameters on media stability and chromatographic property. Stability parameters are of yes/no characteristics while chromatographic parameters are comparable and can be summarized by productivity. Productivity can be divided into dynamic binding capacity, yield and cycle time, with yield influenced by recovery, resolution and cycle time by flow rate, regeneration factor.The hierarchical structure forms an evaluation parameter let for ion exchanger systematic evaluation. Its soundness is supported by statistics of references on media characterization.