Abstract: Based on pinch analysis method and exergy principle, a new approach is developed to optimize the heat-pump integration between low-temperature distillation column and refrigeration system. In this work, our main contribution is dominated to construct the heat-pumping integration exergy grand composite curve, by which the heat-load and temperature level of heat-pump integration between low-temperature distillation column and refrigeration system are visually targeted. Further, the co-efficiency of exergetic performance of heat-pumping integration is presented and formulated, and it is used to quickly evaluate the shiftwork-saving target of refrigeration system resulted from the heat-pump integration. An ethylene plant cold end case study, which requires to de-bottleneck the bad interaction between ethylene column and propylene refrigeration system, is introduced to demonstrate and validate the presented heat-pump integration approach.