关键词: 介孔材料, pH敏感, 温度敏感, 药物控释

Abstract: Mesoporous silica materials with such advantages as high surface area, large pore volume, uniform porosity, stable aqueous dispersion, excellent biocompatibility,non-toxic properties,and the capability to be functionalized with different organic groups could be prepared. Such materials have the basic conditions for drug delivery due to the above advantages. In addition, in biomedical applications, smart intelligent hydrogels can be used for encapsulation of enzymes, controlled drug release, etc. and is also a good drug-carrier material. Smart intelligent hydrogels composites with mesoporous materials with the characteristics of the two materials can be made, and have a broad prospect in application. In this paper,mesoporous molecular sieve(MCM-41) was synthesized by the microwave method,and then composite material MCM-41/P(AA-co-NIPAAm) sensitive to pH value and temperature was synthesized by polymerization of MCM-41 with acrylic acid(AA) and N-isopropylacrylamide(NIPAAm) in situ. The materials were characterized by X-ray diffraction(XRD),nitrogen adsorption-desorption,Fourier transform infrared spectroscopy(FT-IR),and thermogravimetry analysis(TGA).It was found that a new polymer composite was synthesized.The polymer composite exhibited good sensitivities to both temperature and pH. Selecting hydrochlorothiazide as a model drug, the properties of drug loading and release behavior under different pH values and different temperatures were studied with ultraviolet spectrophotometry.  The results showed that composite material MCM-41/P(AA-co-NIPAAm) had a high hydrochlorothiazide storage capacity of 45.8% and hydrochlorothiazide molecules were controlled released from the composite material by adjusting the temperature and pH of the environment. The material released drug faster in simulated intestinal fluid(pH=6.8).When the temperature was higher than 32℃,the release amount would decrease,and when the temperature was lower than 32℃,the release amount would increase significantly. Therefore, this novel MCM-41/P(AA-co-NIPAAm) composite has a potential application to targeted intestinal drug release.Mesoporous silica materials with such advantages as high surface area, large pore volume, uniform porosity, stable aqueous dispersion, excellent biocompatibility,non-toxic properties,and the capability to be functionalized with different organic groups could be prepared. Such materials have the basic conditions for drug delivery due to the above advantages. In addition, in biomedical applications, smart intelligent hydrogels can be used for encapsulation of enzymes, controlled drug release, etc. and is also a good drug-carrier material. Smart intelligent hydrogels composites with mesoporous materials with the characteristics of the two materials can be made, and have a broad prospect in application. In this paper,mesoporous molecular sieve(MCM-41) was synthesized by the microwave method,and then composite material MCM-41/P(AA-co-NIPAAm) sensitive to pH value and temperature was synthesized by polymerization of MCM-41 with acrylic acid(AA) and N-isopropylacrylamide(NIPAAm) in situ. The materials were characterized by X-ray diffraction(XRD),nitrogen adsorption-desorption,Fourier transform infrared spectroscopy(FT-IR),and thermogravimetry analysis(TGA).It was found that a new polymer composite was synthesized.The polymer composite exhibited good sensitivities to both temperature and pH. Selecting hydrochlorothiazide as a model drug, the properties of drug loading and release behavior under different pH values and different temperatures were studied with ultraviolet spectrophotometry.  The results showed that composite material MCM-41/P(AA-co-NIPAAm) had a high hydrochlorothiazide storage capacity of 45.8% and hydrochlorothiazide molecules were controlled released from the composite material by adjusting the temperature and pH of the environment. The material released drug faster in simulated intestinal fluid(pH=6.8).When the temperature was higher than 32℃,the release amount would decrease,and when the temperature was lower than 32℃,the release amount would increase significantly. Therefore, this novel MCM-41/P(AA-co-NIPAAm) composite has a potential application to targeted intestinal drug release.