关键词: 达托霉素, 合成基因簇, 衍生物, 系统生物学, 合成生物学

Abstract: With continuous appearance of highly pathogenic bacteria which are resistant to antibiotics，the need for new antibiotics becomes much pressing in clinical medicine. As the first production of cyclo-lipotpeptied antibiotics daptomycin has effective bactericidal effect to antibiotic resistant bacteria. Because of its convenience in preparation and treatment，as well as insignificant side effects，daptomycin is the perfect replacement of vancomycin recognized as the last line of defense to pathogen. On the basis of introducing physical and chemical characteristics，antimicrobial activity and research achievement of synthetic genetic cluster of daptomycin，this paper mainly summarizes research situation of daptomycin and its derivatives. And the paper also presents perspectives about production of daptomycin and development of its derivatives，including combining with system biology to provide guidance for daptomycin strains’ further metabolic engineering improvement and utilizing synthetic biology to make derivatives of daptomycin new antibiotic.

Key words: daptomycin, synthetic genetic cluster, derivative, system biology, synthetic biology