聚丙烯膜表面磷脂自组装/交联改性及其表面性能

doi:10.3969/j.issn.0438-1157.2013.02.034

化工学报 ›› 2013, Vol. 64 ›› Issue (2): 663-670.DOI: 10.3969/j.issn.0438-1157.2013.02.034

聚丙烯膜表面磷脂自组装/交联改性及其表面性能

王亮^1,2, 宇海银¹, 何桂金², 黄小军²

1. 安徽师范大学化学与材料科学学院,安徽芜湖 241000;
2. 浙江大学高分子科学与工程学系, 化学工程联合国家重点实验室,高分子合成与功能构造教育部重点实验室,浙江杭州 310027

收稿日期:2012-07-25 修回日期:2012-10-16 出版日期:2013-02-05 发布日期:2013-02-05
通讯作者: 黄小军
作者简介:王亮(1986—),男,硕士研究生。
基金资助:
化学工程联合国家重点实验室开放课题项目(SKL-ChE-10D02);浙江省新材料及加工工程省重中之重学科开放课题项目(20110915)。

Surface modification of polypropylene microporous membrane via self-assembly and UV-crosslinking of lecithin and analysis of surface properties

WANG Liang^1,2, YU Haiyin¹, HE Guijin², HUANG Xiaojun²

1. School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, Anhui, China;
2. State Key Laboratory of Chemical Engineering, Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China

Received:2012-07-25 Revised:2012-10-16 Online:2013-02-05 Published:2013-02-05
Supported by:
supported by the State Key Laboratory of Chemical Engineering(SKL-ChE-10D02) and Zhejiang Provincial Top Key Discipline of New Materials and Process Engineering(20110915).

摘要/Abstract

摘要： 发展了一种基于分子自组装/交联的聚丙烯微孔膜(PPMM)表面改性方法,以含不饱和长烷基链的两亲性天然卵磷脂为改性剂,首先通过分子自组装在PPMM表面形成类磷脂组装层,再采用紫外线原位聚合交联方法在PPMM表面构建稳定的类磷脂仿生修饰层,进而赋予PPMM表面优异的亲水性和生物相容性。分别采用FTIR/ATR和XPS分析确证了改性前后膜表面基团及化学成分的变化。通过水接触角测定、荧光标记蛋白质吸附和酶联免疫吸附(ELISA)实验,考察了类磷脂仿生修饰前后膜表面亲水性和抗蛋白质吸附性能,发现类磷脂仿生修饰后PPMM表面水接触角由130°下降至30°,抗蛋白质吸附性能也得到明显改善;自组装/交联改性PPMM经多次水洗后仍能保持良好的亲水性和抗蛋白质吸附性能,表明膜表面所形成的类磷脂仿生修饰层具有良好的稳定性。

关键词: 聚丙烯微孔膜, 卵磷脂, 自组装, 紫外交联, 生物相容性

Abstract: A novel approach to modification of polypropylene microporous membrane (PPMM) surface based on molecular self-assembly and UV-crosslinking was devised.First, natural amphiphilic lecithin was introduced onto the PPMM surface via self-assembly.Then, a stable biomimetic surface analogy with phospholipid layer was constructed through UV-crosslinking of lecithin, conferring the PPMM surface with good hydrophilicity and biocompatibility.The anchoring of lecithin was confirmed by Fourier transformed infrared spectroscopy/attenuated total reflection(FTIR/ATR)and X-ray photoelectron spectroscopy (XPS) studies.Water contact angle, fluorescence labeled protein(FITC-protein)adsorption, and enzyme-linked immuno-sorbent assay (ELISA) were used to evaluate hydrophilicity and biocompatibility of the membrane.Water contact angle of the PPMMs surface was significantly improved after modification, by a decrease from 130? to 30?.Moreover, the modified membranes showed lower protein adsorption.Furthermore, the self-assembly and UV-crosslinking modified membrane exhibited good stability even after multiple washing compared with the self-assembly modified one.

Key words: polypropylene microporous membrane, lecithin, self-assembly, UV-crosslinking, biocompatibility

中图分类号:

O63
TQ028.8

王亮, 宇海银, 何桂金, 黄小军. 聚丙烯膜表面磷脂自组装/交联改性及其表面性能[J]. 化工学报, 2013, 64(2): 663-670.

WANG Liang, YU Haiyin, HE Guijin, HUANG Xiaojun. Surface modification of polypropylene microporous membrane via self-assembly and UV-crosslinking of lecithin and analysis of surface properties[J]. CIESC Journal, 2013, 64(2): 663-670.

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聚丙烯膜表面磷脂自组装/交联改性及其表面性能

Surface modification of polypropylene microporous membrane via self-assembly and UV-crosslinking of lecithin and analysis of surface properties

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