CIESC Journal ›› 2019, Vol. 70 ›› Issue (10): 3825-3835.DOI: 10.11949/0438-1157.20190618

• Reviews and monographs • Previous Articles     Next Articles

Microbial synthesis and transformation of plant-derived natural products

Haijie XUE(),Ying WANG,Chun LI()   

  1. Department of Biochemical Engineering, School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing 100081, China
  • Received:2019-06-04 Revised:2019-07-13 Online:2019-10-05 Published:2019-10-05
  • Contact: Chun LI

植物天然产物的微生物合成与转化

薛海洁(),王颖,李春()   

  1. 北京理工大学化学与化工学院生化工程系,北京 100081
  • 通讯作者: 李春
  • 作者简介:薛海洁(1990—),女,博士研究生,xuehaijie0424@163.com
  • 基金资助:
    国家自然科学基金项目(21736002);国家杰出青年科学基金项目(21425624)

Abstract:

Plant-derived natural products are a class of secondary metabolites with complex structures and diverse properties, which are widely used in food, medicine, cosmetics and other fields. At present, the main source of plant-derived natural products is direct extraction from plants, which is time consuming and farming land occupying. Microbial synthesis has been studied to produce plant-derived natural products for the advantages of short growth cycle, mature manipulating methods and controllable large-scale fermentation. Nowadays, it has attracted many attentions to achieve biosynthesis and transformation of plant-derived natural products employing microbial cells. Many kinds of natural products such as terpenoids, flavonoids, alkaloids and saponins have been successfully synthesized in microbes. In this review, the applications of microbial cell factories in the synthesis of plant-derived natural products have been summarized as well as different strategies, which will be helpful for the systematic and in-depth study in the synthesis and transformation of plant-derived natural products.

Key words: microbial cell factories, plant-derived natural products, biotransformation, terpenoids, flavones, alkaloids

摘要:

植物天然产物是一类结构复杂、性能多样的次级代谢产物,广泛应用于食品、药品、化妆品等多个领域。目前植物天然产物的主要来源依赖于从植物中提取,这种生产方式周期长且占用大量耕地。微生物细胞因其生长周期短、操作简便、环境友好、大规模发酵可控等优势而被广泛研究用以替代传统的植物提取法。目前利用微生物细胞工厂合成和转化植物天然产物已成为研究的热点,实现了萜类、黄酮、生物碱、皂苷等多种植物天然产物的合成和转化。本文分别从从头合成和生物转化的角度综述了微生物细胞工厂在植物天然产物合成中的应用,为更加系统、深入地研究植物天然产物的微生物合成与转化提供参考。

关键词: 微生物细胞工厂, 植物天然产物, 生物转化, 萜类, 黄酮, 生物碱

CLC Number: