CIESC Journal ›› 2024, Vol. 75 ›› Issue (4): 1439-1454.DOI: 10.11949/0438-1157.20231416

• Reviews and monographs • Previous Articles     Next Articles

Advances on continuous-flow synthesis of drugs in microreactors

Xiao XUE(), Minjing SHANG, Yuanhai SU()   

  1. School of Chemistry and Chemical Engineering, Frontiers Science Center of Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2023-12-31 Revised:2024-03-23 Online:2024-06-06 Published:2024-04-25
  • Contact: Yuanhai SU

微反应器内药物连续流合成的研究进展

薛潇(), 商敏静, 苏远海()   

  1. 上海交通大学化学化工学院化工系,教育部变革性分子前沿科学中心,上海 200240
  • 通讯作者: 苏远海
  • 作者简介:薛潇(1993—),女,博士研究生,xuexiao19@sjtu.edu.cn
  • 基金资助:
    国家自然科学基金项目(21676164)

Abstract:

Due to small characteristic size of microreactors, it has a large specific surface area, high mixing efficiency, fast heat and mass transfer efficiency, and can accurately control the reaction process. Compared with the traditional synthesis in batch, the single/multi-step synthesis of drugs in microreactors can achieve the advantages of high selectivity, high efficiency and intrinsic process safety. This article reviews the recent research progress in continuous-flow synthesis of drugs and their intermediates in three commonly used microreactors, including capillary microreactors, plate microreactors and micropacked bed reactors, as well as other new microreactors. The advantages of different types of microreactors are summarized from the perspective of homogeneous and heterogeneous reactions. Finally, the development directions of continuous-flow synthesis of drugs in the future are prospected.

Key words: microreactors, drug, process intensification, kinetics, continuous-flow synthesis

摘要:

由于微反应器的特征尺寸较小,其比表面积大,混合效率高,热质传递效率快,可精确调控反应过程。相比于传统的釜式反应器,在微反应器内开展药物的单步/多步合成,具有高选择性、高效率、本质安全等优势。综述了近年来在三种常用的微反应器包括毛细管微反应器、板式微反应器和微填充床反应器以及其他新型微反应器中进行药物及其中间体连续流合成的研究进展。从均相和非均相反应进行分析,总结了不同类型微反应器的优势。最后,对药物连续流合成的发展方向进行了展望。

关键词: 微反应器, 药物, 过程强化, 动力学, 连续流合成

CLC Number: