Abstract: In this paper,the vacuum evaporative crystallization process of β lactam antimicrobial pharmaceuticals is studied.The crystallization thermodynamic data,such as the phase equilibrium diagram and the metastable zone of pencillin G potassium are determined.Furthermore,the crystallization kinetic parameters for penicillin G potassium salt in n-butanolwater solution are measured by using an unsteady method.Therefore,the optimal operating time table for the crystallization process is established.

摘要： 本文研究了β-内酰胺类抗菌素药物真空闪蒸结晶过程．以苄青霉素钾盐为例，测定了该物系的结晶热力学相图与介稳区曲线，应用间歇动态法确定了该物系的结晶动力学参数，进而求取了最佳操作时间表.