Selective recognition of cefalexin by magnetic molecularly imprinted polymers based on magnetic fly-ash-cenosphere

doi:10.11949/j.issn.0438-1157.20160196

CIESC Journal ›› 2016, Vol. 67 ›› Issue (10): 4273-4281.DOI: 10.11949/j.issn.0438-1157.20160196

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Selective recognition of cefalexin by magnetic molecularly imprinted polymers based on magnetic fly-ash-cenosphere

MAO Yanli¹, LUO Shitian², WU Junfeng¹, LIU Biao¹, KANG Haiyan¹, ZHU Huijie¹, WANG Hongqiang¹, WANG Xiangwen³

1 School of Municipal and Environmental Engineering, Henan University of Urban Construction, Pingdingshan 467036, Henan, China;
2 Construction Engineering Quality Supervise Station of Pingdingshan Construction Commmittee, Pingdingshan 467036, Henan, China;
3 School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan 430074, Hubei, China

Received:2016-02-23 Revised:2016-07-27 Online:2016-10-05 Published:2016-10-05
Supported by:
supported by the National Natural Science Foundation of China (51509083), the Postdoctoral Foundation of China (2011M500870), the Natural Science Foundation of Henan Province (2012HASTTT026) and the Scientific and Technological Foundation of Henan Province (152102210094).

磁性粉煤灰空心微珠表面印迹聚合物选择性识别头孢氨苄

毛艳丽¹, 罗世田², 吴俊峰¹, 刘彪¹, 康海彦¹, 朱慧杰¹, 王红强¹, 王巷文³

1 河南城建学院市政与环境工程学院, 河南平顶山 467036;
2 平顶山市建设工程质量监督站, 河南平顶山 467036;
3 华中科技大学化学与化工学院, 湖北武汉 430074

通讯作者: 毛艳丽
基金资助:
国家自然科学基金项目（51509083）；中国博士后青年基金项目（2011M500870）；河南省高校科技创新人才支持计划项目(2012HASTTT026)；河南省科技攻关项目（152102210094）。

Abstract

Abstract:

Magnetic fly-ash-cenospheres (MFACs) were firstly prepared via an effective coprecipitation method, and then the surface of the MFACs was endowed with reactive vinyl groups through modification with 3-(methacryloyloxy)propyl trimethoxysilane (MPS). Based on the MFACs-MPS, the magnetic molecularly imprinted polymers (MMIPs) were further synthesized for the selective recognition of cefalexin (CFX). MMIPs were characterized by SEM, FT-IR, XRD, TGA and VSM, which indicated that the MMⅡPs exhibited magnetic sensitivity (M_s=12.155 emu·g^-1), thermal stability and the larger specific surface area (123.65 m²·g^-1). Batch mode adsorption studies were carried out to investigate adsorption equilibrium, kinetics and selective recognition. The Langmuir isotherm model was fitted well to the equilibrium data, and the monolayer adsorption capacity of the MMIPs was 69.55 mg·g^-1 at 25℃. The selective recognition experiments demonstrated high affinity and selectivity towards CFX over structurally related antibiotic compounds. Combined with high performance liquid chromatographic analysis technology, the prepared MMⅡPs were successfully applied to the separation of CFX from environmental samples.

Key words: fly-ash-cenosphere, polymers, adsorption, cefalexin, selectivity

摘要：

利用共沉淀法制备了粉煤灰空心微珠磁性复合材料（MFACs），以乙烯基改性的MFACs为基质材料，利用乳液聚合法制备磁性粉煤灰空心微珠表面印迹聚合物（MMIPs）。通过SEM、FT-IR、TGA、XRD和VSM等方法对其物理化学性质进行表征，其比表面积123.65 m²·g^-1，且具有较好的热稳定性、超顺磁性（M_s=12.155 emu·g^-1）。通过系列吸附实验研究表明，Langmuir等温模型能较好地拟合MMIPs对头孢氨苄（cefalexin，CFX）的吸附平衡数据，25℃时MMIPs的单分子层吸附容量为69.55 mg·g^-1。准二级动力学模型能较好地描述MMIPs对CFX吸附动力学行为，选择性实验研究表明，MMIPs对CFX具有较好地选择识别性。结合高效液相色谱分析技术，MMIPs已成功应用于环境样品中痕量CFX的分离/富集。

关键词: 粉煤灰空心微珠, 聚合物, 吸附, 头孢氨苄, 选择性

CLC Number:

X592

MAO Yanli, LUO Shitian, WU Junfeng, LIU Biao, KANG Haiyan, ZHU Huijie, WANG Hongqiang, WANG Xiangwen. Selective recognition of cefalexin by magnetic molecularly imprinted polymers based on magnetic fly-ash-cenosphere[J]. CIESC Journal, 2016, 67(10): 4273-4281.

毛艳丽, 罗世田, 吴俊峰, 刘彪, 康海彦, 朱慧杰, 王红强, 王巷文. 磁性粉煤灰空心微珠表面印迹聚合物选择性识别头孢氨苄[J]. 化工学报, 2016, 67(10): 4273-4281.

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Selective recognition of cefalexin by magnetic molecularly imprinted polymers based on magnetic fly-ash-cenosphere

磁性粉煤灰空心微珠表面印迹聚合物选择性识别头孢氨苄

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