CIESC Journal ›› 2019, Vol. 70 ›› Issue (6): 2060-2074.DOI: 10.11949/j.issn.0438-1157.20181398

• Reviews and monographs • Previous Articles     Next Articles

Research progress of mitochondria-targeted fluorescent probes for ions

Zhiguang YANG(),Xinmei JIANG,Chunyan CHENG,Chaosheng ZHU,Zhiqiang HOU   

  1. College of Chemistry and Chemical Engineering, Zhoukou Normal University, Zhoukou 466001, Henan, China
  • Received:2018-11-22 Revised:2019-03-04 Online:2019-06-05 Published:2019-06-05
  • Contact: Zhiguang YANG

线粒体靶向型离子荧光探针的研究进展

杨志广(),江鑫梅,程春艳,朱超胜,侯志强   

  1. 周口师范学院化学化工学院,河南 周口 466001
  • 通讯作者: 杨志广
  • 基金资助:
    河南省科技厅科技攻关计划项目(182102311110);河南省高等学校重点科研项目计划资助(19A150052)

Abstract:

Mitochondria play a key role in energy metabolism process of cells. A variety of bio-active species in mitochondria, are of great importance in various physiological and pathological processes. The recent advance in organic one and two-photon mitochondria-targeted fluorescent probes for bio-active ions is reviewed. The design mechanism, recognition mechanism, characteristics and biological applications of the fluorescent probes are emphasized in detail, as well as the developing trends of these probes are prospected.

Key words: mitochondria, ions, fluorescent probes, two-photon, selectivity, synthesis, imaging

摘要:

线粒体在细胞的能量代谢过程中发挥着关键作用。线粒体内含有各种生物活性物质,它们在人体各种生理和病理过程中发挥着重要作用。综述了近年来有机单、双光子线粒体靶向型离子荧光探针的研究现状,重点介绍了荧光探针的设计机理、识别机理、特点以及生物应用,并对该类探针的未来发展趋势进行了展望。

关键词: 线粒体, 离子, 荧光探针, 双光子, 选择性, 合成, 成像

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