搅拌釜内液-液混合溶析沉淀法制备纳米姜黄素颗粒

doi:10.3969/j.issn.0438-1157.2013.03.009

化工学报 ›› 2013, Vol. 64 ›› Issue (3): 841-848.DOI: 10.3969/j.issn.0438-1157.2013.03.009

搅拌釜内液-液混合溶析沉淀法制备纳米姜黄素颗粒

赵述芳, 王文坦, 胡银玉, 邵婷, 金涌, 程易

清华大学化学工程系,北京100084

收稿日期:2012-05-17 修回日期:2012-07-16 出版日期:2013-03-05 发布日期:2013-03-05
通讯作者: 程易
作者简介:赵述芳(1989—),女,博士研究生。
基金资助:
国家自然科学基金项目(20776074,20906057);高等学校博士学科点专项科研基金项目(20090002110069)。

Liquid mixing and Curcumin nanoparticle preparation in stirred tanks

ZHAO Shufang, WANG Wentan, HU Yinyu, SHAO Ting, JIN Yong, CHENG Yi

Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

Received:2012-05-17 Revised:2012-07-16 Online:2013-03-05 Published:2013-03-05
Supported by:
supported by the National Natural Science Foundation of China(20776074,20906057)and the Specialized Research Fund for the Doctoral Program of Higher Education(20090002110069).

摘要/Abstract

摘要： 研究了在搅拌釜内利用溶析沉淀法制备姜黄素纳米颗粒的过程,分别探讨了搅拌釜尺寸、搅拌形式、初始浓度以及搅拌转速对制备结果的影响。通过平面激光诱导荧光技术定量测量釜内液液混合行为,揭示了流体混合环境的控制是决定溶析沉淀产品过程的关键因素。实验表明,搅拌速度过低无法保证流体混合效率,将导致颗粒黏结;搅拌速度过高带来颗粒与流场的强剪切作用,引起颗粒破碎;局部过饱和度过大,引起颗粒的生长和聚团。搅拌釜内纳米颗粒制备需提供适度强化的流体混合环境。

关键词: 搅拌釜, 溶析沉淀, 激光诱导荧光技术, 姜黄素, 纳米颗粒

Abstract: The preparation of Curcumin nanoparticles was realized in a small stirred tank by the anti-solvent precipitation process.The influences of such factors as tank size,stirring style,initial concentration and rotation speed on nanoparticle preparation were investigated.Meanwhile,planar laser induced fluorescence (PLIF) technique was used to quantitatively measure the liquid-liquid mixing performance in the tank,and the mixing environment was found to be important for the preparation of nanoparticles.A low stirring speed in a small stirred tank with a turbine impeller could not achieve the desired mixing efficiency because of agglomeration of nanoparticles.An overly high stirring speed brought in strong shearing interaction between particles and fluid so that many particles were broken up.Overly high over-saturation in local areas would cause growth and agglomeration of particles.The optimal mixing environment with moderate process intensification was crucial to successfully prepare high quality Curcumin nanoparticles with spherical shape and narrow size distribution.

Key words: stirred tank, anti-solvent precipitation, PLIF technique, Curcumin, nanoparticle

中图分类号:

TQ027.3

赵述芳, 王文坦, 胡银玉, 邵婷, 金涌, 程易. 搅拌釜内液-液混合溶析沉淀法制备纳米姜黄素颗粒[J]. 化工学报, 2013, 64(3): 841-848.

ZHAO Shufang, WANG Wentan, HU Yinyu, SHAO Ting, JIN Yong, CHENG Yi. Liquid mixing and Curcumin nanoparticle preparation in stirred tanks[J]. CIESC Journal, 2013, 64(3): 841-848.

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搅拌釜内液-液混合溶析沉淀法制备纳米姜黄素颗粒

Liquid mixing and Curcumin nanoparticle preparation in stirred tanks

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