CIESC Journal ›› 2024, Vol. 75 ›› Issue (11): 4217-4225.DOI: 10.11949/0438-1157.20240457
• Fluid dynamics and transport phenomena • Previous Articles Next Articles
Zihao ZHONG(), Sai'er LIU, Minjing SHANG, Yuanhai SU(
)
Received:
2024-04-25
Revised:
2024-05-26
Online:
2024-12-26
Published:
2024-11-25
Contact:
Yuanhai SU
通讯作者:
苏远海
作者简介:
钟子豪(1999—),男,硕士研究生,z395598971@sjtu.edu.cn
基金资助:
CLC Number:
Zihao ZHONG, Sai'er LIU, Minjing SHANG, Yuanhai SU. Flow characteristics and micromixing performance of micro-CSTR with magnetic stirring[J]. CIESC Journal, 2024, 75(11): 4217-4225.
钟子豪, 刘塞尔, 商敏静, 苏远海. 基于磁力搅拌的微型CSTR流动特征及微观混合性能[J]. 化工学报, 2024, 75(11): 4217-4225.
Entry | Reactor system | Rotary speed /(r/min) | Flow rate / (ml/min) | Mean residence time/s | Pe | N | ||
---|---|---|---|---|---|---|---|---|
Theoretical | Experimental | |||||||
1 | micro-CSTR | 1000 | 0.8 | 240.00 | 222.80 | 0.0941 | 20.20 | 10.6 |
2 | 1000 | 1.2 | 160.00 | 167.68 | 0.0839 | 22.78 | 11.9 | |
3 | 1000 | 1.6 | 120.00 | 123.10 | 0.0842 | 22.71 | 11.9 | |
4 | 1000 | 2 | 96.00 | 106.13 | 0.0798 | 24.02 | 12.5 | |
5 | 1000 | 2.4 | 80.00 | 86.56 | 0.0812 | 23.58 | 12.3 | |
6 | 1000 | 2.8 | 68.00 | 69.83 | 0.0804 | 23.83 | 12.4 | |
7 | 0 | 1.6 | 120.00 | 133.04 | 0.0694 | 27.79 | 14.4 | |
8 | 200 | 1.6 | 120.00 | 138.43 | 0.0729 | 26.41 | 13.7 | |
9 | 600 | 1.6 | 120.00 | 136.34 | 0.0820 | 23.33 | 12.2 | |
10 | 800 | 1.6 | 120.00 | 134.60 | 0.0844 | 22.66 | 11.8 | |
11 | capillary microreactor | — | 0.8 | 382.00 | 369.55 | 0.0238 | 82.93 | — |
12 | — | 1.6 | 191.00 | 192.04 | 0.0584 | 33.19 | — | |
13 | — | 2.4 | 127.00 | 143.27 | 0.0804 | 23.84 | — |
Table 1 Residence time distribution measurement data
Entry | Reactor system | Rotary speed /(r/min) | Flow rate / (ml/min) | Mean residence time/s | Pe | N | ||
---|---|---|---|---|---|---|---|---|
Theoretical | Experimental | |||||||
1 | micro-CSTR | 1000 | 0.8 | 240.00 | 222.80 | 0.0941 | 20.20 | 10.6 |
2 | 1000 | 1.2 | 160.00 | 167.68 | 0.0839 | 22.78 | 11.9 | |
3 | 1000 | 1.6 | 120.00 | 123.10 | 0.0842 | 22.71 | 11.9 | |
4 | 1000 | 2 | 96.00 | 106.13 | 0.0798 | 24.02 | 12.5 | |
5 | 1000 | 2.4 | 80.00 | 86.56 | 0.0812 | 23.58 | 12.3 | |
6 | 1000 | 2.8 | 68.00 | 69.83 | 0.0804 | 23.83 | 12.4 | |
7 | 0 | 1.6 | 120.00 | 133.04 | 0.0694 | 27.79 | 14.4 | |
8 | 200 | 1.6 | 120.00 | 138.43 | 0.0729 | 26.41 | 13.7 | |
9 | 600 | 1.6 | 120.00 | 136.34 | 0.0820 | 23.33 | 12.2 | |
10 | 800 | 1.6 | 120.00 | 134.60 | 0.0844 | 22.66 | 11.8 | |
11 | capillary microreactor | — | 0.8 | 382.00 | 369.55 | 0.0238 | 82.93 | — |
12 | — | 1.6 | 191.00 | 192.04 | 0.0584 | 33.19 | — | |
13 | — | 2.4 | 127.00 | 143.27 | 0.0804 | 23.84 | — |
1 | Jähnisch K, Hessel V, Löwe H, et al. Chemistry in microstructured reactors[J]. Angewandte Chemie (International Ed. in English), 2004, 43(4): 406-446. |
2 | Jas G, Kirschning A. Continuous flow techniques in organic synthesis[J]. Chemistry-A European Journal, 2003, 9(23): 5708-5723. |
3 | Malet-Sanz L, Susanne F. Continuous flow synthesis. A pharma perspective[J]. Journal of Medicinal Chemistry, 2012, 55(9): 4062-4098. |
4 | Hughes D L. Applications of flow chemistry in drug development: highlights of recent patent literature [J]. Organic Process Research & Development, 2018, 22(1): 13-20. |
5 | Stueckler C, Hermsen P, Ritzen B, et al. Development of a continuous flow process for a matteson reaction: from lab scale to full-scale production of a pharmaceutical intermediate [J]. Organic Process Research & Development, 2019, 23(5): 1069-1077. |
6 | Zong J, Yue J. Continuous solid particle flow in microreactors for efficient chemical conversion[J]. Industrial & Engineering Chemistry Research, 2022, 61(19): 6269-6291. |
7 | Henry C, Minier J P, Lefèvre G. Towards a description of particulate fouling: from single particle deposition to clogging [J]. Advances in Colloid and Interface Science, 2012, 185/186: 34-76. |
8 | Liedtke A K, Bornette F, Philippe R, et al. Gas-liquid-solid "slurry taylor" flow: experimental evaluation through the catalytic hydrogenation of 3-methyl-1-pentyn-3-ol[J]. Chemical Engineering Journal, 2013, 227: 174-181. |
9 | Zhao S N, Yao C Q, Dong Z Y, et al. Role of ultrasonic oscillation in chemical processes in microreactors: a mesoscale issue[J]. Particuology, 2020, 48: 88-99. |
10 | Bannock J H, Krishnadasan S H, Nightingale A M, et al. Continuous synthesis of device-grade semiconducting polymers in droplet-based microreactors[J]. Advanced Functional Materials, 2013, 23(17): 2123-2129. |
11 | Noël T, Naber J R, Hartman R L, et al. Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation[J]. Chemical Science, 2011, 2(2): 287-290. |
12 | Hartman R L, Naber J R, Zaborenko N, et al. Overcoming the challenges of solid bridging and constriction during Pd-catalyzed C—N bond formation in microreactors [J]. Organic Process Research & Development, 2010, 14(6): 1347-1357. |
13 | Khan S A, Günther A, Schmidt M A, et al. Microfluidic synthesis of colloidal silica [J]. Langmuir, 2004, 20(20): 8604-8611. |
14 | Khan S A, Jensen K F. Microfluidic synthesis of titania shells on colloidal silica [J]. Advanced Materials, 2007, 19(18): 2556-2560. |
15 | 董正亚, 陈光文, 赵帅南, 等. 声化学微反应器——超声和微反应器协同强化[J]. 化工学报, 2018, 69(1): 102-115. |
Dong Z Y, Chen G W, Zhao S N, et al. Sonochemical microreactor-synergistic intensification of ultrasound and microreactor[J]. CIESC Journal, 2018, 69(1): 102-115. | |
16 | Mo Y M, Jensen K F. A miniature CSTR cascade for continuous flow of reactions containing solids[J]. Reaction Chemistry & Engineering, 2016, 1(5): 501-507. |
17 | Pomberger A, Mo Y M, Nandiwale K Y, et al. A continuous stirred-tank reactor (CSTR) cascade for handling solid-containing photochemical reactions[J]. Organic Process Research & Development, 2019, 23(12): 2699-2706. |
18 | Hopley A, Doyle B J, Roberge D M, et al. Residence time distribution in coil and plate micro-reactors[J]. Chemical Engineering Science, 2019, 207: 181-193. |
19 | 陈光文, 袁权. 微化工技术[J]. 化工学报, 2003, 54(4): 427-439. |
Chen G W, Yuan Q. Micro-chemical technology[J]. Journal of Chemical Industry and Engineering (China), 2003, 54(4): 427-439. | |
20 | Othman R, Vladisavljević G T, Hemaka Bandulasena H C, et al. Production of polymeric nanoparticles by micromixing in a co-flow microfluidic glass capillary device[J]. Chemical Engineering Journal, 2015, 280: 316-329. |
21 | Xu C, Zhong Y J, Zheng Y N, et al. Micromixing-assisted preparation of TiO2 films from ammonium hexafluorotitanate and urea by liquid phase deposition based on simulation of mixing process in T-shaped micromixer[J]. Ceramics International, 2019, 45(9): 11325-11334. |
22 | Chang Y J, Mugdur P, Han S Y, et al. Nanocrystalline CdS MISFETs fabricated by a novel continuous flow microreactor [J]. Electrochemical and Solid State Letters, 2006, 9(5): 174. |
23 | Lobasov A S, Minakov A V, Kuznetsov V V, et al. Investigation of mixing efficiency and pressure drop in T-shaped micromixers [J]. Chemical Engineering and Processing-Process Intensification, 2018, 134: 105-114. |
24 | 骆广生, 徐建鸿, 陈桂光, 等. 微结构设备内液-液均相混合性能研究进展[J]. 现代化工, 2005, 25(11): 19-23. |
Luo G S, Xu J H, Chen G G, et al. Advances in research of liquid-liquid homogeneous mixing performance in micro-structured devices[J]. Modern Chemical Industry, 2005, 25(11): 19-23. | |
25 | Rahimi M, Aghel B, Hatamifar B, et al. CFD modeling of mixing intensification assisted with ultrasound wave in a T-type microreactor [J]. Chemical Engineering and Processing: Process Intensification, 2014, 86: 36-46. |
26 | Fournier M C, Falk L, Villermaux J. A new parallel competing reaction system for assessing micromixing efficiency—experimental approach[J]. Chemical Engineering Science, 1996, 51(22): 5053-5064. |
27 | Fournier M C, Falk L, Villermaux J. A new parallel competing reaction system for assessing micromixing efficiency—determination of micromixing time by a simple mixing model[J]. Chemical Engineering Science, 1996, 51(23): 5187-5192. |
28 | Reis M H, Varner T P, Leibfarth F A. The influence of residence time distribution on continuous-flow polymerization[J]. Macromolecules, 2019, 52(9): 3551-3557. |
29 | Wong S H, Ward M C L, Wharton C W. Micro T-mixer as a rapid mixing micromixer[J]. Sensors and Actuators B: Chemical, 2004, 100(3): 359-379. |
30 | Hoffmann M, Schlüter M, Räbiger N. Experimental investigation of liquid-liquid mixing in T-shaped micro-mixers using μ-LIF and μ-PIV[J]. Chemical Engineering Science, 2006, 61(9): 2968-2976. |
[1] | Qirui GUO, Liyuan REN, Kang CHEN, Xiangyu HUANG, Weihua MA, Leqin XIAO, Weiliang ZHOU. Numerical simulation of static mixing tubes for HTPB propellant slurry [J]. CIESC Journal, 2024, 75(S1): 206-216. |
[2] | Zichi YANG, Bingqi XIE, Ruixin SHI, Hong LEI, Chen CHEN, Caijin ZHOU, Jisong ZHANG. Research progress on efficient and safe gas-liquid mass transfer and reaction processes in tube-in-tube reactor [J]. CIESC Journal, 2024, 75(9): 3011-3027. |
[3] | Fei LU, Bona LU, Guangwen XU. Analysis of criteria for ideal flow patterns in gas-solid micro fluidized bed reaction analyzer [J]. CIESC Journal, 2024, 75(6): 2201-2213. |
[4] | Jiayu XU, Feiguo CHEN, Ji XU, Wei GE. Multiscale mixing index for granular systems [J]. CIESC Journal, 2024, 75(6): 2214-2221. |
[5] | Xiao XUE, Minjing SHANG, Yuanhai SU. Advances on continuous-flow synthesis of drugs in microreactors [J]. CIESC Journal, 2024, 75(4): 1439-1454. |
[6] | Yuhang HE, Dan XIE, Yangcheng LYU. Research progress of cationic polymerization in microreactor [J]. CIESC Journal, 2024, 75(4): 1302-1316. |
[7] | Baiping XU, Ruifeng LIANG, Huiwen YU, Guiqun WU, Shuping XIAO. Simulation of intra-cavity distribution mixing under the action of enhanced triangular rotor of twin-screw extruder [J]. CIESC Journal, 2024, 75(3): 858-866. |
[8] | Rao CHEN, Xin ZHAO, Daixin CHEN, Shengkun JIANG, Yingjiang LIAN, Jinbo WANG, Mei YANG, Guangwen CHEN. Continuous dinitration of toluene to dinitrotoluene in a microreactor [J]. CIESC Journal, 2024, 75(3): 867-876. |
[9] | Nan TU, Xiaoqun LIU, Chiyu WANG, Jiabin FANG. Study on adaptability of scaling law to residence time distribution in bubbling fluidized beds with continuous operation [J]. CIESC Journal, 2024, 75(2): 543-552. |
[10] | Xiaobin ZHAN, Huibin WANG, Yalong JIANG, Tielin SHI. Research on power consumption characteristics of high viscosity fluid mixing in acoustic resonance mixer [J]. CIESC Journal, 2024, 75(2): 531-542. |
[11] | Lin WANG, Rongding JIANG, Chunxiao ZHANG, Xiuzhen LI, Yingying TAN. Evaluation and predictive study of the mixing rules for vapor-liquid equilibrium of R1234yf mixtures [J]. CIESC Journal, 2024, 75(2): 475-483. |
[12] | Zhengya DONG, Xiaojing ZHU, Jingfu JIA, Jie ZHANG, Zhuotao ZHENG, Xiaolin LIU, Zhilin WU. Scale-up of ultrasonic microreactor systems and their applications in the preparation of nanomaterials [J]. CIESC Journal, 2024, 75(11): 4095-4119. |
[13] | Jing SONG, Yujun WANG, Jian DENG, Guangwen CHEN, Guangsheng LUO. Research progress of aromatic nitration reaction in microreactors [J]. CIESC Journal, 2024, 75(11): 3911-3922. |
[14] | Fajun WANG, An CHEN, Jianhong XU. Continuous-flow synthesis of Pigment Red 57 in a microreactor system [J]. CIESC Journal, 2024, 75(10): 3600-3609. |
[15] | Deyin GU, Changshu LI, Hao YANG, Zuohua LIU. Fluid chaotic mixing behavior intensified by fractal-arranged perforated impeller [J]. CIESC Journal, 2024, 75(10): 3498-3506. |
Viewed | ||||||||||||||||||||||||||||||||||||||||||||||||||
Full text 173
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||
Abstract 166
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||