Preparation and performance evaluation of LDH-PTFPMS/PEI composite membrane for improving blood compatibility and CO2 transfer

doi:10.11949/0438-1157.20240996

CIESC Journal ›› 2025, Vol. 76 ›› Issue (4): 1800-1808.DOI: 10.11949/0438-1157.20240996

• Material science and engineering, nanotechnology • Previous Articles Next Articles

Preparation and performance evaluation of LDH-PTFPMS/PEI composite membrane for improving blood compatibility and CO₂transfer

Xiaokun WANG¹^,⁵(), Zelin LIAO², Junliang WU³, Xingyu CHEN³, Yifei YU³, Gaohong HE¹^,⁴(), Xiujuan ZHANG²^,⁴()

^1.State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China
^2.State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Ocean and Life Science, Dalian University of Technology, Panjin 124000, Liaoning, China
^3.Leicester International Institute, Dalian University of Technology, Panjin 124000, Liaoning, China
^4.R&D Center of Membrane Science and Technology, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China
^5.Pulmonary and Critical Care Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, China

Received:2024-09-03 Revised:2024-11-21 Online:2025-05-12 Published:2025-04-25
Contact: Gaohong HE, Xiujuan ZHANG

提升血液相容性及促进CO₂传递的LDH-PTFPMS/PEI复合膜制备及性能评价

王晓琨¹^,⁵(), 廖泽林², 武俊良³, 陈星宇³, 于奕菲³, 贺高红¹^,⁴(), 张秀娟²^,⁴()

^1.大连理工大学化工学院精细化工全国重点实验室，智能材料化工前沿科学中心，辽宁大连 116024
^2.大连理工大学化工海洋与生命学院，精细化工全国重点实验室，辽宁盘锦 124000
^3.大连理工大学莱斯特国际学院，辽宁盘锦 124000
^4.大连理工大学化工学院，膜科学与技术研究开发中心，辽宁大连 116024
^5.大连大学附属中山医院呼吸与危重症医学科一科，辽宁大连 116001

通讯作者: 贺高红,张秀娟
作者简介:王晓琨（1982—），女，博士研究生，287057159@qq.com
基金资助:
国家自然科学基金创新群体项目(22021005);辽宁省自然科学基金项目(2023-MS-114)

Abstract

Abstract:

Extra-corporeal membrane oxygenation (ECMO) provides vital extracorporeal life support for critically ill patients. The main commercial oxygenating membrane, core component of ECMO, microporous polypropylene (PP) exhibits good gas permeability but easy blood leakage because of the micropores, while poly(4-methyl-1-pentene) (PMP) shows great difficulty in synthesis, and the hydrophobicity of both membranes often leads to poor blood compatibility. In this research, matrix mixed membranes LDH-PTFPMS/PEI, with the hydrophobic PTFPMS modified with the hydrophilic, bio-compatible and hydroxyl-group rich layered double hydroxide (LDH) as the dense functional separational layer and the microporous PEI membrane as the supporting layer, was synthesized, characterized for their structure as well as morphology, and evaluated for their performance in gas transfer and blood compatibility. The results showed that the addition of LDH promoted the permeability of CO₂in the membrane. Compared with the original PTFPMS/PEI membrane, the CO₂ permeability of the 4% LDH-PTFPMS/PEI membrane increased by nearly 50% under normal pressure (0.1 MPa), and the membrane's anti-protein adsorption and platelet adhesion properties were improved, among which BSA protein adsorption was reduced by 21%.

Key words: ECMO, LDH, composite membranes, hemocompatibility, gas permeance

摘要：

体外膜肺氧合（ECMO）为危重症患者提供重要体外生命支持，其核心部件氧合膜微孔聚丙烯（PP）膜气透性能好，但微孔存在易漏血的风险；而聚-4-甲基-1-戊烯（PMP）非对称膜制备困难，且两种材料本身疏水，存在血液相容性差等问题。利用亲水、生物相容性好且富含羟基的层状双氢氧化物（LDH）改性聚三氟丙基甲基硅氧烷（PTFPMS），制备了含有LDH-PTFPMS致密分离层的LDH-PTFPMS/PEI复合膜，并研究了LDH改性对膜形貌结构、膜气透性及血液相容性等的影响。结果表明，LDH的加入促进了CO₂在膜中的渗透率，与原PTFPMS/PEI膜相比，常压（0.1 MPa）下，4% LDH-PTFPMS/PEI膜的CO₂渗透率较原膜提高近50%，且提升了膜的抗蛋白吸附及血小板黏附性能，其中BSA蛋白吸附量降低了21%。

关键词: ECMO, LDH, 复合膜, 血液相容性, 气透性

CLC Number:

R 318.08

Xiaokun WANG, Zelin LIAO, Junliang WU, Xingyu CHEN, Yifei YU, Gaohong HE, Xiujuan ZHANG. Preparation and performance evaluation of LDH-PTFPMS/PEI composite membrane for improving blood compatibility and CO₂transfer[J]. CIESC Journal, 2025, 76(4): 1800-1808.

王晓琨, 廖泽林, 武俊良, 陈星宇, 于奕菲, 贺高红, 张秀娟. 提升血液相容性及促进CO₂传递的LDH-PTFPMS/PEI复合膜制备及性能评价[J]. 化工学报, 2025, 76(4): 1800-1808.

Figures/Tables 8

Fig.1 Characterization and analysis on Mg-Al LDH

Fig.2 SEM images of membrane top surfaces and cross-sections

Fig.3 FTIR and TGA analyses on the composite membranes

Fig.4 Water contact angle of membranes

Fig.5 Hemolysis ratios of the membranes（*means P<0.05）

Fig.6 SEM images of platelet adhesion onto the membrane surface

Fig.7 Static protein adsorption onto membrane surface (n.s. means P > 0.05；* means P<0.05；** means P<0.01)

Fig.8 (a) The gas permeability and CO2/O2 selectivity of membranes at 0.1 MPa; (b) CO2 gas permeation rate of membranes under different pressure

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