Preparation of BaSO4 nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

doi:10.11949/j.issn.0438-1157.20180779

Abstract

Abstract:

BaCl₂ and Na₂SO₄ were used as raw materials to prepare cubic nano-BaSO₄ particles by microchannel reactor, and characterized by SEM and XRD. The effects of different reaction methods and microchannel reactor structures, volume flows of reactants, the concentration, temperature, volume flow ratio on size and morphology of BaSO₄ nanoparticles were investigated. The suitable reaction condition applied to multifunctional layer of amylase medical dry film was obtained with volume flow of 2.5 ml/min, reactant concentration of 0.1 mol/L, the temperature of 25℃ and volume flow ratio of 5. At the same time, compared with the direct precipitation method, the nano-BaSO₄ particles prepared in the microchannel reactor had a regular morphology with particle size from 25 nm to 55 nm. The prepared BaSO₄ multi-functional layers were applied to the amylase medical slides with an obvious color gradient. The signal value decreased in turn using the densitometer, and the repeatability and stability of signal value curve were better, which indicated that the prepared BaSO₄ particles could be applied to the multi-functional layer of the amylase in vitro diagnostic reagent.

Key words: microreactor, synthesis, nanoparticles, medical slices

摘要：

以BaCl₂和Na₂SO₄为原料，采用微通道反应器制备得到立方形纳米BaSO₄颗粒，并通过SEM、XRD对其进行表征。考察了不同反应方式及微通道反应器结构、反应物体积流量、反应物浓度、反应温度、体积流量比对纳米BaSO₄颗粒大小和形貌的影响。实验结果表明：25℃下，体积流量为2.5 ml/min，反应物浓度为0.1 mol/L，体积流量比为5是应用于淀粉酶医用干片多功能层的纳米BaSO₄颗粒合成的最佳反应条件。与直接沉淀法相比，微通道反应器内制备出的纳米BaSO₄颗粒形貌规整，最终得到产物粒径为25～55 nm。将所制备的BaSO₄多功能层应用到淀粉酶医用干片中，颜色梯度明显，经反射光密度仪检测，信号值依次减小，且信号值变化曲线重复性、稳定性较好，说明制备的BaSO₄颗粒可应用于淀粉酶体外诊断试剂中多功能层上。

关键词: 微反应器, 合成, 纳米粒子, 医用干片

CLC Number:

TQ 027

Feifei YE, Baodan ZHANG, Haibo JIN, Xiaoyan GUO, Guangxiang HE, Rongyue ZHANG, Qingyang GU, Suohe YANG. Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices[J]. CIESC Journal, 2019, 70(3): 1179-1187.

叶飞飞, 张宝丹, 靳海波, 郭晓燕, 何广湘, 张荣月, 谷庆阳, 杨索和. 微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用[J]. 化工学报, 2019, 70(3): 1179-1187.

Figures/Tables 10

Fig.1 Experimental flowchart for preparing BaSO4 nanoparticles

Fig.2 SEM micrographs of BaSO4 nanoparticles with different microchannel reactors

Fig.3 XRD patterns of BaSO4 nanoparticles

Fig.4 SEM micrographs of BaSO4 nanoparticles with different volume flows

Fig.5 SEM micrographs of BaSO4 nanoparticles with different reactant concentrations

Fig.6 SEM micrographs of BaSO4 nanoparticles with different temperatures

Fig. 7 SEM micrographs of BaSO4 nanoparticles with different VA/VB

Fig.8 SEM micrographs of multi-functional layers with different BaSO4 nanoparticles

Fig.9 Light reflection signal chart and spot image of different concentrations of amylase

Fig.10 Light reflection signal chart of different concentrations of amylase

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Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用

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