A Non-linear Non-ideal Model of Simulated Moving Bed Chromatography for Chiral Separations

Abstract

Abstract: A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial
dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was
developed to simulate the dynamics of simulated moving bed chromatography (SMBC). The model
equations were solved by a new efficient numerical technique of orthogonal collocation on
finite elements with periodical movement of concentration vector. The simulated SMBC
performance is in accordance with the experimental results reported in the literature for
separation of 1,1’-bi-2-naphthol enantiomers using SMBC. This model is useful for design,
operation, optimization and scale-up of non-linear SMBC for chiral separations with
significant non-ideal effects, especially for high solute concentration and small
intraparticle diffusion coefficient or large chiral stationary phase particle.

Key words: simulated moving bed chromatography, chiral separation, non-linear isotherm, non-ideal effect, dynamics

摘要： A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial
dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was
developed to simulate the dynamics of simulated moving bed chromatography (SMBC). The model
equations were solved by a new efficient numerical technique of orthogonal collocation on
finite elements with periodical movement of concentration vector. The simulated SMBC
performance is in accordance with the experimental results reported in the literature for
separation of 1,1’-bi-2-naphthol enantiomers using SMBC. This model is useful for design,
operation, optimization and scale-up of non-linear SMBC for chiral separations with
significant non-ideal effects, especially for high solute concentration and small
intraparticle diffusion coefficient or large chiral stationary phase particle.

关键词: simulated moving bed chromatography;chiral separation;non-linear isotherm;non-ideal effect;dynamics

LU Jiangang. A Non-linear Non-ideal Model of Simulated Moving Bed Chromatography for Chiral Separations[J]. .

卢建刚. 模拟移动床色谱手性分离过程的非线性非理想模型[J]. CIESC Journal.

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