Abstract: In order to increase the safety of chemical process,researchers proposed many methods and strategies,some quantitative indices have been developed to describe the potential hazard and dangerous of different reaction route and reactant.In this paper,the stability was considered as a factor to indicate the process safety,and a quantitative analysis of the capability of resistance to disturbance of stable steady-state points were conducted,then the fermentation process and MMA process were studied to demonstrate the effectiveness of the proposed method.

Key words: inherently safer, multiplicity, stability, quantitative disturbance range

摘要： 为了从源头上设计本质安全化的化工过程，研究人员提出多种本质安全化的设计方法和策略，先后开发了多种用来比较不同反应路径中有害物质潜在威胁的定量评价指数。本文将化工过程的稳定性作为一个重要因素来研究本质安全化的化工过程的设计方法，通过研究化工过程稳定的稳态解能够承受的扰动范围，提出抗扰动能力指数定量说明稳定解对于扰动的承受能力。本文通过分析厌氧发酵过程和甲基丙烯酸甲酯聚合过程，定量计算存在多稳态解区域的稳定解能够承受的扰动范围，这对于设计本质安全化的化工过程具有重要意义。

关键词: 本质安全化, 多稳态, 稳定性, 定量扰动范围