Abstract: Amphiphilic polymers have a wide range of applications in biomedicine and nanotechnology because of their unique structures with both hydrophilic chains and hydrophobic chains. Research progress of aggregates formed by molecular self-assembly of amphiphilic polymers is introduced. Some molecular self-assembled aggregates，such as aggregates controlled by structure，composition and molecular weight，semi-crystalline aggregates，crosslinked aggregates，smart aggregates with stimuli-responsiveness (such as pH，temperature，pH/temperature，redox，solvent polarity) are discussed. Research efforts have been focused on controllability of amphiphilic polymers structure and enhancement of stability of aggregates. Crystallization induced molecular self-assembly and smart molecular self-assembly are future research trends.

Key words: amphiphilic polymers, molecular self-assembly, aggregation, nanoparticles, morphology

摘要： 两亲性聚合物以其同时具有亲水和疏水链段的独特结构，在生物医药、纳米技术等领域有广泛的用途。本文主要介绍了两亲性聚合物通过分子自组装形成聚集体的研究进展，详细论述了几种分子自组装聚集体的制备，包括结构、组成、分子量控制的简单聚集体、半结晶聚集体、交联聚集体以及具有刺激响应性（pH值响应性、温度响应性、pH值/温度双重响应性、氧化还原响应性、溶剂极性响应性等）的智能型聚集体，两亲性聚合物结构的可控性以及如何提高聚集体的稳定性成为国内外专家研究的重点，指出结晶诱导分子自组装及智能型分子自组装是未来研究的热点。

关键词: 两亲性聚合物, 分子自组装, 聚集作用, 纳米粒子, 形态学