关键词: 1,3-丙二醇, 分离工艺, 流程模拟, 生产成本, 敏感性分析

Abstract: The preliminary design for the bioconversion of 1,3-propanediol from glycerol with annual production capacity of 1000 tons was achieved by three separation processes operated sequentially，which were an aqueous two-phase extraction，an alcohol precipitation and an electrodialysis．The process simulation software，ProⅡ，was used to simulate the three downstream processes．Based on energy and material balance，the raw material，utilities and equipments costs of these three processes were calculated．The cost analysis indicated that the total costs of alcohol precipitation，aqueous two-phase extraction and electrodialysis were 14793，14201 and 14345（RMB/t），respectively．The economic sensitivity analysis showed that the price of glycerol was the key factor influencing the unit costs．The increasing of the concentration and yield of 1,3-propanediol will help to reduce production costs and improve process economic efficiency．

Key words: 1,3-propanediol, separation processes, process simulation, production cost, sensitivity analysis