头孢地嗪钠溶剂化物结晶过程自催化动力学

doi:10.3969/j.issn.0438-1157.2013.02.020

化工学报 ›› 2013, Vol. 64 ›› Issue (2): 555-560.DOI: 10.3969/j.issn.0438-1157.2013.02.020

• 催化、动力学与反应器 • 上一篇下一篇

头孢地嗪钠溶剂化物结晶过程自催化动力学

张信伟^1,2, 尹秋响¹, 刘增坤¹, 龚俊波¹

1. 天津大学化工学院,化学工程联合国家重点实验室,天津 300072;
2. 中国石油化工股份有限公司抚顺石油化工研究院,辽宁抚顺 113001

收稿日期:2012-08-24 修回日期:2012-12-04 出版日期:2013-02-05 发布日期:2013-02-05
通讯作者: 龚俊波
作者简介:张信伟(1982—),男,博士研究生。
基金资助:
国家自然科学基金项目(20836005,21176173);天津市自然科学基金项目(10JCYBJC14200,11JCZDJC20700);化学工程联合国家重点实验室开放课题项目(SKL-ChE-11B02)。

Autocatalytic kinetics of cefodizime sodium solvate in crystallization

ZHANG Xinwei^1,2, YIN Qiuxiang¹, LIU Zengkun¹, GONG Junbo¹

1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2. Fushun Research Institute of Petroleum and Petrochemicals, SINOPEC, Fushun 113001, Liaoning, China

Received:2012-08-24 Revised:2012-12-04 Online:2013-02-05 Published:2013-02-05
Supported by:
supported by the National Natural Science Foundation of China (20836005, 21176173),Tianjin Municipal Natural Science Foundation (10JCYBJC14200,11JCZDJC20700) and the State Key Laboratory of Chemical Engineering (SKL-ChE-11B02).

摘要/Abstract

摘要： 采用在线拉曼光谱在不同结晶温度和溶液初始浓度的条件下,研究了头孢地嗪钠溶剂化物结晶过程的动力学行为,从热力学和成核机理的角度分析了温度和初始浓度对动力学的影响。根据动力学曲线的特征,将头孢地嗪钠溶剂化物的结晶过程假定为"自催化"过程。针对头孢地嗪钠溶剂化物结晶过程的特殊性,修正了Prout-Tompkins模型;并通过不同温度下的动力学数据,采用多元线性回归拟合了头孢地嗪钠溶剂化物结晶过程的自催化动力学模型参数E和k。

关键词: 头孢地嗪钠, 溶剂化物, 结晶, Prout-Tompkins模型, 自催化动力学

Abstract: The analysis on the crystallization of cefodizime sodium solvate shows that the conversion-time curve presents three characteristics:S-shape, the turning-point, and the turning-point corresponding to the maximum crystallization rate.Therefore, the crystallization of cefodizime sodium solvate could be assumed as an autocatalytic process, and the Prout-Tompkins model was modified according to the solubility curve in order to apply in solution crystallization.The autocatalytic kinetics of solvate crystallization was studied at different temperatures and initial concentrations.The effect of temperature was explained from two aspects:thermodynamics and nucleation mechanism.The kinetic parameters (activation energy E and pre-exponential factor k) of the autocatalytic kinetic models were estimated by multiple linear regression method.

Key words: cefodizime sodium, solvate, crystallization, Prout-Tompkins model, autocatalytic kinetics

中图分类号:

TQ032.4

张信伟, 尹秋响, 刘增坤, 龚俊波. 头孢地嗪钠溶剂化物结晶过程自催化动力学[J]. 化工学报, 2013, 64(2): 555-560.

ZHANG Xinwei, YIN Qiuxiang, LIU Zengkun, GONG Junbo. Autocatalytic kinetics of cefodizime sodium solvate in crystallization[J]. CIESC Journal, 2013, 64(2): 555-560.

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头孢地嗪钠溶剂化物结晶过程自催化动力学

Autocatalytic kinetics of cefodizime sodium solvate in crystallization

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