关键词: (R)-3, 5-双三氟甲基苯乙醇, 动力学拆分, 3, 5-双三氟甲基苯乙酮。

Abstract: (R,S)-3,5-bis(tri?uoromethyl)phenyl ethanol was prepared by reduction of 3,5-bis (tri?uoromethyl) acetophenone with the NaBH4 as reducing agent. Two efficient and highly selective lipases，Novozym 435 and Rhizopus arrhizus，were screened with (R,S)-3,5- bis(tri?uoromethyl)phenyl ethanol as substrate. Rhizopus arrhizus was selected as our experimental lipase and the factors which affected kinetic resolution were studied. When n-hexane was selected as solvent，optically pure (R)-3,5- bis (trifluoromethyl) phenyl ethyl acetate could be obtained after 30 min at 40 ℃. After post-processing，we obtained (R)-3,5-bis (trifluoromethyl) phenyl ethyl with the e.e. value of 100%.

Key words: (R)-3,5-bis(tri?uoromethyl)phenyl ethanol, kinetic resolution, 3,5-bis(tri?uoromethyl) acetophenone