化工学报 ›› 2019, Vol. 70 ›› Issue (3): 1179-1187.DOI: 10.11949/j.issn.0438-1157.20180779

• 材料化学工程与纳米技术 • 上一篇    下一篇

微通道反应器合成纳米BaSO4颗粒及其在干片多功能层上的应用

叶飞飞1,2(),张宝丹1,靳海波1(),郭晓燕1,何广湘1,张荣月1,谷庆阳1,杨索和1   

  1. 1. 北京石油化工学院化学工程学院,燃料清洁化及高效催化减排技术北京市重点实验室,北京 102617
    2. 北京化工大学化学工程学院,北京 100029
  • 收稿日期:2018-07-10 修回日期:2018-12-18 出版日期:2019-03-05 发布日期:2019-03-05
  • 通讯作者: 靳海波
  • 作者简介:<named-content content-type="corresp-name">叶飞飞</named-content>(1991—),女,硕士研究生,<email>yefeifei91@163.com</email>|靳海波(1969—),男,博士,教授,<email>jinhaibo@bipt.edu.cn</email>
  • 基金资助:
    国家自然科学基金重大研究计划项目(91634101);北京市属高校高水平教师队伍建设支持计划高水平创新团队建设计划项目(IDHT20180508)

Preparation of BaSO4 nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

Feifei YE1,2(),Baodan ZHANG1,Haibo JIN1(),Xiaoyan GUO1,Guangxiang HE1,Rongyue ZHANG1,Qingyang GU1,Suohe YANG1   

  1. 1. School of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology, Beijing 102617, China
    2. College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2018-07-10 Revised:2018-12-18 Online:2019-03-05 Published:2019-03-05
  • Contact: Haibo JIN

摘要:

以BaCl2和Na2SO4为原料,采用微通道反应器制备得到立方形纳米BaSO4颗粒,并通过SEM、XRD对其进行表征。考察了不同反应方式及微通道反应器结构、反应物体积流量、反应物浓度、反应温度、体积流量比对纳米BaSO4颗粒大小和形貌的影响。实验结果表明:25℃下,体积流量为2.5 ml/min,反应物浓度为0.1 mol/L,体积流量比为5是应用于淀粉酶医用干片多功能层的纳米BaSO4颗粒合成的最佳反应条件。与直接沉淀法相比,微通道反应器内制备出的纳米BaSO4颗粒形貌规整,最终得到产物粒径为25~55 nm。将所制备的BaSO4多功能层应用到淀粉酶医用干片中,颜色梯度明显,经反射光密度仪检测,信号值依次减小,且信号值变化曲线重复性、稳定性较好,说明制备的BaSO4颗粒可应用于淀粉酶体外诊断试剂中多功能层上。

关键词: 微反应器, 合成, 纳米粒子, 医用干片

Abstract:

BaCl2 and Na2SO4 were used as raw materials to prepare cubic nano-BaSO4 particles by microchannel reactor, and characterized by SEM and XRD. The effects of different reaction methods and microchannel reactor structures, volume flows of reactants, the concentration, temperature, volume flow ratio on size and morphology of BaSO4 nanoparticles were investigated. The suitable reaction condition applied to multifunctional layer of amylase medical dry film was obtained with volume flow of 2.5 ml/min, reactant concentration of 0.1 mol/L, the temperature of 25℃ and volume flow ratio of 5. At the same time, compared with the direct precipitation method, the nano-BaSO4 particles prepared in the microchannel reactor had a regular morphology with particle size from 25 nm to 55 nm. The prepared BaSO4 multi-functional layers were applied to the amylase medical slides with an obvious color gradient. The signal value decreased in turn using the densitometer, and the repeatability and stability of signal value curve were better, which indicated that the prepared BaSO4 particles could be applied to the multi-functional layer of the amylase in vitro diagnostic reagent.

Key words: microreactor, synthesis, nanoparticles, medical slices

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