微通道反应器合成纳米BaSO4颗粒及其在干片多功能层上的应用

doi:10.11949/j.issn.0438-1157.20180779

化工学报 ›› 2019, Vol. 70 ›› Issue (3): 1179-1187.DOI: 10.11949/j.issn.0438-1157.20180779

• 材料化学工程与纳米技术 • 上一篇下一篇

微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用

叶飞飞^1,²(),张宝丹¹,靳海波¹(),郭晓燕¹,何广湘¹,张荣月¹,谷庆阳¹,杨索和¹

1. 北京石油化工学院化学工程学院，燃料清洁化及高效催化减排技术北京市重点实验室，北京 102617
2. 北京化工大学化学工程学院，北京 100029

收稿日期:2018-07-10 修回日期:2018-12-18 出版日期:2019-03-05 发布日期:2019-03-05
通讯作者: 靳海波
作者简介:<named-content content-type="corresp-name">叶飞飞</named-content>（1991—），女，硕士研究生，<email>yefeifei91@163.com</email>|靳海波（1969—），男，博士，教授，<email>jinhaibo@bipt.edu.cn</email>
基金资助:
国家自然科学基金重大研究计划项目(91634101);北京市属高校高水平教师队伍建设支持计划高水平创新团队建设计划项目(IDHT20180508)

Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

Feifei YE^1,²(),Baodan ZHANG¹,Haibo JIN¹(),Xiaoyan GUO¹,Guangxiang HE¹,Rongyue ZHANG¹,Qingyang GU¹,Suohe YANG¹

1. School of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology, Beijing 102617, China
2. College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China

Received:2018-07-10 Revised:2018-12-18 Online:2019-03-05 Published:2019-03-05
Contact: Haibo JIN

摘要/Abstract

摘要：

以BaCl₂和Na₂SO₄为原料，采用微通道反应器制备得到立方形纳米BaSO₄颗粒，并通过SEM、XRD对其进行表征。考察了不同反应方式及微通道反应器结构、反应物体积流量、反应物浓度、反应温度、体积流量比对纳米BaSO₄颗粒大小和形貌的影响。实验结果表明：25℃下，体积流量为2.5 ml/min，反应物浓度为0.1 mol/L，体积流量比为5是应用于淀粉酶医用干片多功能层的纳米BaSO₄颗粒合成的最佳反应条件。与直接沉淀法相比，微通道反应器内制备出的纳米BaSO₄颗粒形貌规整，最终得到产物粒径为25～55 nm。将所制备的BaSO₄多功能层应用到淀粉酶医用干片中，颜色梯度明显，经反射光密度仪检测，信号值依次减小，且信号值变化曲线重复性、稳定性较好，说明制备的BaSO₄颗粒可应用于淀粉酶体外诊断试剂中多功能层上。

关键词: 微反应器, 合成, 纳米粒子, 医用干片

Abstract:

BaCl₂ and Na₂SO₄ were used as raw materials to prepare cubic nano-BaSO₄ particles by microchannel reactor, and characterized by SEM and XRD. The effects of different reaction methods and microchannel reactor structures, volume flows of reactants, the concentration, temperature, volume flow ratio on size and morphology of BaSO₄ nanoparticles were investigated. The suitable reaction condition applied to multifunctional layer of amylase medical dry film was obtained with volume flow of 2.5 ml/min, reactant concentration of 0.1 mol/L, the temperature of 25℃ and volume flow ratio of 5. At the same time, compared with the direct precipitation method, the nano-BaSO₄ particles prepared in the microchannel reactor had a regular morphology with particle size from 25 nm to 55 nm. The prepared BaSO₄ multi-functional layers were applied to the amylase medical slides with an obvious color gradient. The signal value decreased in turn using the densitometer, and the repeatability and stability of signal value curve were better, which indicated that the prepared BaSO₄ particles could be applied to the multi-functional layer of the amylase in vitro diagnostic reagent.

Key words: microreactor, synthesis, nanoparticles, medical slices

中图分类号:

TQ 027

叶飞飞, 张宝丹, 靳海波, 郭晓燕, 何广湘, 张荣月, 谷庆阳, 杨索和. 微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用[J]. 化工学报, 2019, 70(3): 1179-1187.

Feifei YE, Baodan ZHANG, Haibo JIN, Xiaoyan GUO, Guangxiang HE, Rongyue ZHANG, Qingyang GU, Suohe YANG. Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices[J]. CIESC Journal, 2019, 70(3): 1179-1187.

图/表 10

图1 制备纳米BaSO4颗粒实验流程

Fig.1 Experimental flowchart for preparing BaSO4 nanoparticles

图2 反应器形式对纳米BaSO4颗粒影响的SEM图

Fig.2 SEM micrographs of BaSO4 nanoparticles with different microchannel reactors

图3 纳米BaSO4颗粒的XRD谱图

Fig.3 XRD patterns of BaSO4 nanoparticles

图4 不同体积流量时纳米BaSO4颗粒的SEM图

Fig.4 SEM micrographs of BaSO4 nanoparticles with different volume flows

图5 不同反应物浓度时纳米BaSO4颗粒的SEM图

Fig.5 SEM micrographs of BaSO4 nanoparticles with different reactant concentrations

图6 不同反应温度时纳米BaSO4颗粒的SEM图

Fig.6 SEM micrographs of BaSO4 nanoparticles with different temperatures

图7 不同VA/VB时纳米BaSO4颗粒的SEM图

Fig. 7 SEM micrographs of BaSO4 nanoparticles with different VA/VB

图8 不同类型BaSO4所制多功能层的SEM图

Fig.8 SEM micrographs of multi-functional layers with different BaSO4 nanoparticles

图9 不同浓度淀粉酶反应后信号值与反应斑点图

Fig.9 Light reflection signal chart and spot image of different concentrations of amylase

图10 不同浓度淀粉酶反应后信号值变化

Fig.10 Light reflection signal chart of different concentrations of amylase

参考文献 30

1	WinndeenE S, DavidH, SiglerG, et al. Development of a direct assay for a α-amylase[J]. Clinical Chemistry, 1988, 34(10): 2005-2008.
2	MorishitaY, IinumaY, NakashimaN, et al. Total and pancreatic amylase measured with 2-chloro-4-nitrophenyl-4-o-b-dgalactopyranosylmaltoside[J]. Clinical Chemistry, 2000, 46(7): 928-933.
3	LapekasP. New technologies for laboratory productivity[J]. Journal of Healthcare Material Management, 1994, 12(3): 30-34.
4	NgR H, SparksK M, StatlandB E. Colorimetric determination of potassium in plasma and serum by reflectance photometry with a dry-chemistry reagent[J]. Clinical Chemistry, 1992, 38(7): 1371-1372.
5	张利娟, 薄惠, 杨滨红, 等. 干化学分析技术在临床检验中的应用[J]. 广东化工, 2015, 42(17): 94-95.
	ZhangL J, BoH, YangB H, et al. The application of dry chemical analysis technology in clinical laboratory[J]. Guangdong Chemical Industry, 2015, 42(17): 94-95.
6	VogelsbergerW, SchmidtJ. Studies of the solubility of BaSO₄ nanoparticles in water: kinetic size effect, solubility product, and influence of microporosity[J]. The Journal of Physical Chemistry, 2010, 115: 1388-1397.
7	陈虞亮, 张雷. 纳米硫酸钡的研究进展[J]. 广东化工, 2013, 40(18): 69-70.
	ChenY L, ZhangL. Research progress of nanometer barium sulfate[J]. Guangdong Chemical Industry, 2013, 40(18): 69-70.
8	RamaswamyV, VimalathithaN R M, PonnusamyV. Preparation of barium sulphate nanocrystals in ethanol - water mixed solvents[J]. Journal of Ceramic Processing Research, 2011, 12(2): 173-175.
9	GuptaA, SinghC, ShivakumaraC. Synthesis of BaSO₄ nanoparticles by precipitation method using sodium hexa metaphosphate as a stabilizer[J]. Solid State Communications, 2010, 150 : 386-388.
10	HuL N, WangG X, YangC. Fabrication of submicron barium sulfate aggregates in the presence of ethylenediaminetetraacetic acid anions[J]. Particuology, 2015, 22(5): 157-162.
11	LiuY J, GuoX Y, YangS H, et al. Controllable preparation of uniform micron-sized barium-sulfate spheres[J]. Crystal Research and Technology, 2018, 53(6): 201700212.
12	ZhangM, ZhangB, LiX H, et al. Synthesis and surface properties of submicron barium sulfate particles[J]. Applied Surface Science, 2011, 258: 24-29.
13	QiL M, MaJ M, ChengH M, et al. Preparation of BaSO₄ nanoparticles in non-ionic w/o microemulsions[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1996, 108: 117-126.
14	叶飞飞, 郭晓燕, 侯静, 等. 双微乳液法制备纳米硫酸钡颗粒[J]. 化工学报, 2018, 69(6): 429-436.
	YeF F, GuoX Y, HouJ, et al. Synthesis of BaSO₄ nanoparticles by double microemulsion method[J]. CIESC Journal, 2018, 69(6): 429-436.
15	YingY, ChenG, ZhaoY, et al. A high throughput methodology for continuous preparation of monidipersed nanocrystals in microfluidic reactors[J]. Chemical Engineering Journal, 2008, 135(3): 209-215.
16	MiyazakiM, KanenoJ, KohamaR, et al. Preparation of functionalized nanostructures on microchannel surface and their use for enzyme microreactors[J]. Chemical Engineering Journal, 2004, (101): 277-284.
17	BotheaD, StemichC, WarneckeH J. Fluid mixing in a T-shaped micro-mixer[J]. Chemical Engineering Science, 2006, 61(9): 2950-2958.
18	鞠景喜, 曾昌凤, 张利雄, 等. 微通道反应器在微-纳米材料合成中的应用研究进展[J]. 化工进展, 2006, 25(2): 152-157.
	JuJ X, ZengC F, ZhangL X, et al. Development of the application of microchannel reactors in the synthesis of micro/nanoparticles[J]. Chemical Industry and Engineering Progress, 2006, 25(2): 152-157.
19	MiyazakiM, KanenoJ, KohamaR, et al. Preparation of functionalized nanostructures on microchannel surface and their use for enzyme microreactors[J]. Chemical Engineering Journal, 2004, 101: 277-284.
20	JeevarathinamD, GuptaA K, PitchumaniB, et al. Effect of gas and liquid flowrates on the size distribution of barium sulfate nanoparticles precipitated in a two-phase flow capillary microreactor[J]. Chemical Engineering Journal, 2011, 173: 607-611.
21	PalanisamyB, PaulB. Continuous flow synthesis of ceria nanoparticles using static T-mixers[J]. Chemical Engineering Science, 2012, 78 (34): 46-52.
22	SueK, KimuraK, AraiK. Hydrothermal synthesis of ZnO nanocrystals using microreactor[J]. Materials Letters, 2004, 58: 3229-3231.
23	WangQ, WangJ X, LiM, et al. Large-scale preparation of barium sulphate nanoparticles in a high-throughput tube-in-tube microchannel reactor[J]. Chemical Engineering Journal, 2009, 149(1): 473-478.
24	王琦安, 王洁欣, 余文, 等. 微通道反应器微观混合效率的实验研究[J]. 北京化工大学学报(自然科学版), 2009, 36(3): 1-5.
	WangQ A, WangJ X, YuW, et al. An experimental study of the micromixing efficiency in microchannel reactors[J]. Journal of Beijing University of Chemical Technology (Natural Science), 2009, 36(3): 1-5.
25	赵玉潮, 应盈, 陈光文, 等. T形微混合器内的混合特性[J]. 化工学报, 2006, 57(8): 1884-1890.
	ZhaoY C, YingY, ChenG W, et al. Characterization of micro-mixing in T-shaped micro-mixer[J]. Journal of Chemical Industry and Engineering (China), 2006, 57(8): 1884-1890.
26	任郑玲, 卢晨阳, 王安杰, 等. T 型微混合器合成 Cu₂O 纳米颗粒[J]. 化工学报, 2017, 68(6): 2611-2617.
	RenZ L, LuC Y, WangA J, et al. Synthesis of Cu₂O nanoparticles in T-shaped micro-mixer[J]. CIESC Journal, 2017, 68(6): 2611-2617.
27	向阳, 王琦安, 杨旷, 等. 微通道反应器中反应沉淀过程的工艺研究[J]. 高校化学工程学报, 2009, 23(3): 474-479.
	XiangY, WangQ A, YangK, et al. Study of reactive precipitation in microchannel reactors[J]. Journal of Chemical Engineering of Chinese Universities, 2009, 23(3): 474-479.
28	张乾霞, 娄金婷, 周月, 等. 微通道反应器内纳米头孢呋辛酯制备工艺优化[J]. 北京化工大学学报, 2011, 38(1): 15-20.
	ZhangQ X, LouJ T, ZhouY, et al. Optimization of the preparation of cefuroxime axetil nanoparticles in a microchannel by orthogonal tests[J]. Journal of Beijing University of Chemical Technology(Natural Science), 2011, 38(1): 15-20.
29	任俊英, 刘进荣. 硫酸钠浓度对纳米硫酸钡粒径和粒度分布的影响[J]. 中国科技信息, 2013, 13: 39-39.
	RenJ Y, LiuJ R. Effect of sodium sulfate concentration on particle size and size distribution of nano-barium sulfate[J]. China Science and Technology Information, 2013, 13: 39-39.
30	尚小琴, 陈兰英, 郑成. 染色淀粉膜法测定α -淀粉酶的研究[J]. 广东化工, 2006, 34(3): 41-43.
	ShangX Q, ChenL Y, ZhengC.Mensuration of α-amylase by dye-starch film[J].Guangdong Chemical Industry, 2006, 34(3): 41-43.

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微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用

Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

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