Experiment and simulation on multi-stage countercurrent centrifugal extraction of naproxen enantiomers

doi:10.3969/j.issn.0438-1157.2013.11.026

CIESC Journal ›› 2013, Vol. 64 ›› Issue (11): 4074-4081.DOI: 10.3969/j.issn.0438-1157.2013.11.026

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Experiment and simulation on multi-stage countercurrent centrifugal extraction of naproxen enantiomers

TANG Kewen^1,2, WEN Ping², ZHANG Panliang¹, HUANG Yan¹

1. Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, Hunan, China;
2. Department of Chemical Engineering, Xiangtan University, Xiangtan 411105, Hunan, China

Received:2013-04-04 Revised:2013-06-30 Online:2013-11-05 Published:2013-11-05
Supported by:
supported by the National Natural Science Foundation of China(21176062),the Natural Science Foundation of Hunan Province(12JJ2007),the Scientific Research Fund of Hunan Provincial Education Department(12B053),the Science and Technology Planning Project of Hunan Province(2012GK3107)and the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

多级离心逆流萃取萘普生对映体模拟及实验研究

唐课文^1,2, 文平², 张盼良¹, 黄燕¹

1. 湖南理工学院化学化工学院, 湖南岳阳 414006;
2. 湘潭大学化工学院, 湖南湘潭 411105

通讯作者: 唐课文
作者简介:唐课文(1970-),男,教授。
基金资助:
国家自然科学基金项目(21176062);湖南省自然科学基金项目(12JJ2007);湖南省教育厅科学研究基金项目(12B053);湖南省科技计划项目(2012GK3107);湖南省高校科技创新团队支持计划项目。

Abstract

Abstract: Based on the single-stage model for chiral extraction of naproxen(NAP)enantiomers and the law of mass conservation,a model for multi-stage countercurrent centrifugal extraction of naproxen enantiomers was built.The model was programmed with Matlab and the influence of process parameters such as phase ratio,extractant concentration,pH value of aqueous phase was examined.Increase of phase ratio(W/O)reduces the enantiomeric excess(ee_extract)and increases the yield(Y_extract)in the extract. With the increase of extractant concentration,ee_extract of extract increases quickly at first,then decreases slowly,and Y_extract increases continuously.As pH increases,Y_extract keeps increase,while ee_extract decreases.The experimental and simulation studies indicate that ee_extract of 45% and Y_extract of 60% are achieved under the optimal separation conditions:R,S-NAP concentration of 0.025 mol·L^-1,HP-β-CD concentration of 0.050 mol·L^-1,phase ratio of 7,pH of 2.5,and temperature of 5℃.

Key words: naproxen, computer simulation, extraction, centrifugal contactor separator, modeling

摘要： 基于萘普生(NAP)对映体的单级手性萃取数学模型和质量守恒定律,建立了多级离心逆流萃取萘普生对映体数学模型。采用Matlab语言编写程序模拟了相比、萃取剂浓度、水相pH值等参数对萃取相出口对映体过剩量和产率的影响,并经实验研究对模型模拟进行验证。结果表明:采用中间进料,对映体浓度[R,S-NAP]=0.025 mol·L^-1、萃取剂浓度[C]=0.050 mol·L^-1、相比W/O=7、水相pH=2.5、温度T=5℃时,经10级离心逆流萃取后萃取相出口S-NAP对映体过剩量为45%,相应的产率60%,实验结果和模型模拟值符合得很好。

关键词: 萘普生, 计算机模拟, 萃取, 离心分离器, 模型

CLC Number:

TANG Kewen, WEN Ping, ZHANG Panliang, HUANG Yan. Experiment and simulation on multi-stage countercurrent centrifugal extraction of naproxen enantiomers[J]. CIESC Journal, 2013, 64(11): 4074-4081.

唐课文, 文平, 张盼良, 黄燕. 多级离心逆流萃取萘普生对映体模拟及实验研究[J]. 化工学报, 2013, 64(11): 4074-4081.

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Experiment and simulation on multi-stage countercurrent centrifugal extraction of naproxen enantiomers

多级离心逆流萃取萘普生对映体模拟及实验研究

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