Abstract: The solubilities of two -agonists, cimaterol and mabuterol, insupercritical carbon dioxide
(SF-CO2) were measured by arecirculating method at temperatures of 40 C and 60 C
andpressures between 9 MPa to 49 MPa. The compounds exhibit very limitedsolubilities in the
range of 10-5 to 10-7 (mole fraction).Cimaterol has a higher solubility than that of
mabuterol. Theexperimental data of solubility were correlated by four density-basedmodels.
The correlation accuracy highly depends on the systeminvestigated, which is mainly
determined by the density ranges andtemperature.

Key words: β-agonists, cimaterol, mabuterol, supercritical carbon dioxide, solubilityminipage

摘要： The solubilities of two -agonists, cimaterol and mabuterol, insupercritical carbon dioxide
(SF-CO2) were measured by arecirculating method at temperatures of 40 C and 60 C
andpressures between 9 MPa to 49 MPa. The compounds exhibit very limitedsolubilities in the
range of 10-5 to 10-7 (mole fraction).Cimaterol has a higher solubility than that of
mabuterol. Theexperimental data of solubility were correlated by four density-basedmodels.
The correlation accuracy highly depends on the systeminvestigated, which is mainly
determined by the density ranges andtemperature.

关键词: β-agonists;cimaterol;mabuterol;supercritical carbon dioxide;solubilityminipage