Abstract: A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluoroacetophenone,
via oxaly lation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation
and piperazination. The reaction temperature is moderate and the operation is easily
controlled. Additional four new compounds are prepared by the method.

Key words: ciprofloxacin, synthesis, quinolone

摘要： A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluoroacetophenone,
via oxaly lation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation
and piperazination. The reaction temperature is moderate and the operation is easily
controlled. Additional four new compounds are prepared by the method.

关键词: ciprofloxacin;synthesis;quinolone