Abstract: Brush copolymers with poly(ethylene glycol) (PEG) as side chains have received wide attentions due to their unique properties and potential applications. In this article，the synthesis strategies，including “grafting through” and “grafting onto”，their speci?c advantages and limitations are reviewed，with an emphasis on brush PEG copolymers based on biodegradable materials，such as polyesters. In each strategy，various polymerization techniques，such as ionic polymerization，radical polymerization，ring opening polymerization and their compatible partner various coupling reactions，are employed. Meanwhile，the surface morphologies of the micelles built from linear PEG copolymers and brush PEG copolymers are illustrated in this article，and the effects of the architecture of PEG brush on the formed nanoparticles’ properties in drug delivery are briefly discussed. Well-de?ned brush PEG structure can prolong circulation times，resulting in improvement in drug efficacy. However，the effective synthetic methods as well as the micelles’ in vivo and in vitro properties still need ongoing and further researches.

Key words: poly(ethylene glycol), brush copolymers, synthesis, drug delivery properties, nanomaterials, surface

摘要： 刷状聚乙二醇（PEG）两亲性共聚物具有独特的性能和良好的应用前景，日益受到人们的重视。本文综述了刷状PEG两亲性共聚物的两种合成策略，即大分子单体法和主链-侧链偶联法，它们主要通过离子聚合、自由基聚合、开环聚合及各种耦合反应等实现。举例分析了这些方法的优缺点，并侧重于聚酯等生物可降解材料形成的刷状PEG共聚物。比较了直链PEG和刷状PEG共聚物胶束表面形态，简要分析了刷状PEG结构对纳米颗粒药物输送性能的影响，指出刷状PEG结构能延长体内循环时间从而提高药物疗效，但有效的合成方法及其胶束的体内外性能还需要更深入的探索。

关键词: 聚乙二醇, 刷状共聚物, 合成, 药物输送性能, 纳米材料, 表面