Abstract: Decomposition of acetone cyanohydrin is the first-step reaction for preparing (S)-α-cyano
-3-phenoxybenzyl alcohol (CPBA) by the one-pot method in organic media. Considering the
compatibility of bio-catalysts with chemical catalysts and the successive operation in the
bioreactor, anion exchange resin (D301) wasused as catalyst for this reaction. External
diffusion limitation was excluded by raising rotational speed to higherthan 190r@min-1 in
both solvents. Internal diffusion limitation was verified to be insignificant in this
reactionsystem. The effect of acetone cyanohydrin concentration on the reaction was also
investigated. An intrinsic kineticmodel was proposed when the mass transfer limitation was
excluded, and the average deviation of the model is10.5%.

Key words: acetone cyanohydrin, model, organic media, anion-exchange resin

摘要： Decomposition of acetone cyanohydrin is the first-step reaction for preparing (S)-α-cyano
-3-phenoxybenzyl alcohol (CPBA) by the one-pot method in organic media. Considering the
compatibility of bio-catalysts with chemical catalysts and the successive operation in the
bioreactor, anion exchange resin (D301) wasused as catalyst for this reaction. External
diffusion limitation was excluded by raising rotational speed to higherthan 190r@min-1 in
both solvents. Internal diffusion limitation was verified to be insignificant in this
reactionsystem. The effect of acetone cyanohydrin concentration on the reaction was also
investigated. An intrinsic kineticmodel was proposed when the mass transfer limitation was
excluded, and the average deviation of the model is10.5%.

关键词: acetone cyanohydrin;model;organic media;anion-exchange resin