CIESC Journal ›› 2016, Vol. 67 ›› Issue (1): 176-190.DOI: 10.11949/j.issn.0438-1157.20151007

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Progress in research of mitochondrial fluorescence probes

JIANG Na1,2, FAN Jiangli1, YANG Hongbao1, PENG Xiaojun1   

  1. 1 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, Liaoning, China;
    2 School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
  • Received:2015-06-29 Revised:2015-07-31 Online:2016-01-05 Published:2016-01-05
  • Supported by:

    supported by the National Natural Science Foundation of China (21136002, 21422601, 21421005), the National Basic Research Program of China (2013CB733702), Ministry of Education (NCET-12-0080) and the Natural Science Foundation of Liaoning Province (2013020115).

线粒体荧光探针最新研究进展

姜娜1,2, 樊江莉1, 杨洪宝1, 彭孝军1   

  1. 1 大连理工大学精细化工国家重点实验室, 辽宁 大连 116024;
    2 济南大学化学化工学院, 山东 济南 250022
  • 通讯作者: 彭孝军
  • 基金资助:

    国家自然科学基金项目(21136002,21422601,21421005);国家重点基础研究发展计划项目(2013CB733702);教育部新世纪优秀人才支持计划(NCET-12-0080);辽宁省自然科学基金项目(2013020115)。

Abstract:

The researches on organelles are important ways to study the structure and function of cells. Mitochondria, the principal energy-producing compartments in most cells, play roles in the numerous vital cellular processes. Thus, the organelles are crucially involved in various pathologies. As one of the most important cellular organelles, mitochondria are always the focus of researches. There are three kinds of mitochondrial fluorescence probes. This paper mainly introduces and discusses the progresses of mitochondrial staining kind of fluorescent probes in recent 10 years on the basis of the fluorophore with positive charge or the introduction of positioning groups such as triphenylphosphine.

Key words: fluorescence, probe, mitochondria, cell biology, biotechnology, imaging

摘要:

细胞器的研究一直是认识细胞结构和功能的重要手段。线粒体是细胞的能量工厂,参与众多的新陈代谢过程,许多病理学过程均与它相关,是一种重要的细胞器,一直以来都是研究的热点。定位于线粒体的荧光探针主要分为3大类,本文重点介绍并讨论近10年基于带有正电荷的荧光团或者在荧光团中引入三苯基膦等定位基团实现对线粒体染色荧光探针的研究进展。

关键词: 荧光, 探针, 线粒体, 细胞生物学, 生物技术, 成像

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