CIESC Journal ›› 2022, Vol. 73 ›› Issue (6): 2381-2396.doi: 10.11949/0438-1157.20220063

• Reviews and monographs • Previous Articles     Next Articles

Research progress on amyloid β-protein aggregation and its regulation

Wei LIU(),Yan SUN()   

  1. School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300350, China
  • Received:2022-01-12 Revised:2022-05-04 Online:2022-06-05 Published:2022-06-30
  • Contact: Yan SUN;


The spontaneous aggregation of β-amyloid (amyloid β-protein, Aβ) forms a large number of toxic oligomers, which lead to the death of neurons in the brain, thereby causing cognitive impairment, namely Alzheimer's disease (AD). Serious threat to human health. At present, lack of the understanding of the multiscale Aβ oligomers has seriously restricted the design and development of Aβ modulators or inhibitors. This review is devoted to introduction of the fundamentals of the on-pathway Aβ aggregation and the relationship with mesoscience, classification of the various mesoscale Aβ oligomers generated during Aβ assembly, and the cytotoxicity mediated by the Aβ oligomers. Then, the design strategies, inhibitory mechanisms, and functions of different modulators or inhibitors developed to date are discussed. Finally, major challenges on the development of Aβ-associated AD drugs are addressed and the future research into this crucial field is proposed.

Key words: Alzheimer's disease, amyloid β-protein, multiscale, aggregation, modulation, biomedical engineering

CLC Number: 

  • TQ 460.1
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