CIESC Journal ›› 2022, Vol. 73 ›› Issue (10): 4285-4297.DOI: 10.11949/0438-1157.20220468

• Reviews and monographs • Previous Articles     Next Articles

Advances in crystallization of ultrafine crystals

Haifeng ZHENG(), Shengzhe JIA, Songcheng WANG, Rui HAN, Dandan HAN, Zhenguo GAO(), Junbo GONG   

  1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • Received:2022-04-01 Revised:2022-07-25 Online:2022-11-02 Published:2022-10-05
  • Contact: Zhenguo GAO

超细晶体的研究进展

郑海峰(), 贾晟哲, 王崧成, 韩瑞, 韩丹丹, 高振国(), 龚俊波   

  1. 天津大学化工学院,化学工程联合国家重点实验室,天津 300072
  • 通讯作者: 高振国
  • 作者简介:郑海峰(1998—),男,硕士研究生,zhenghf207112@tju.edu.cn
  • 基金资助:
    山东省重点研发计划项目(重大科技创新工程)(2021CXGC01051);国家自然科学基金青年项目(22008173)

Abstract:

Ultrafine crystals are widely used in the medicine and chemical industry due to their smaller size and larger specific surface area. In this paper, the preparation methods of ultrafine crystals, principles and controlled parameters of particle size are reviewed in detail. The applications of ultrafine crystals in inhalation, energetic materials and poorly water insoluble drugs were summarized. Meanwhile, the stability of ultrafine crystals suspensions and particle aggregation were reviewed. Finally, we outlook the future development of ultrafine crystals.

Key words: crystallization, particle formation, stability, ultrafine crystal, agglomeration

摘要:

超细晶体由于其尺寸小、比表面积大等独特性质而被广泛应用于医药、化工等领域。综述了超细晶体的制备方法,以及各种制备方法的原理和粒度控制参数。总结了超细晶体在吸入剂、含能材料以及难溶药物等领域的应用,同时对超细晶体悬浮液的稳定性、颗粒聚结进行了讨论分析,并对超细晶体的发展提出展望。

关键词: 结晶, 粒子形成, 稳定性, 超细晶体, 聚结

CLC Number: