核壳结构磁性纳米复合物的合成及载药性能

doi:10.11949/j.issn.0438-1157.20180305

化工学报 ›› 2018, Vol. 69 ›› Issue (S1): 170-175.DOI: 10.11949/j.issn.0438-1157.20180305

• 材料化学工程与纳米技术 • 上一篇下一篇

核壳结构磁性纳米复合物的合成及载药性能

贾尚宁, 常娟娟, 李宁波, 乔洁

山西医科大学基础医学院, 山西太原 030001

收稿日期:2018-03-21 修回日期:2018-03-28 出版日期:2018-09-30 发布日期:2018-09-30
通讯作者: 乔洁,E-mail:qiaojie@smxu.edu.cn
基金资助:
山西省自然科学基金项目（2013011012-5）；331山西医科大学基础医学院科技培植基金项目（201421）。

Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties

JIA Shangning, CHANG Juanjuan, LI Ningbo, QIAO Jie

School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi, China

Received:2018-03-21 Revised:2018-03-28 Online:2018-09-30 Published:2018-09-30
Supported by:
supported by the Natural Science Foundation of Shanxi Province (2013011012-5) and the 331 Early Career Researcher Grant of Basic Medical College (201421).

摘要/Abstract

摘要：

利用化学交联法合成了壳聚糖改性的四氧化三铁磁性纳米复合物。通过透射电子显微镜（TEM）、傅里叶转换红外光谱（FTIR）、粒度分析仪（Nano-ZS）和振动样品磁强计（VSM）对该复合物的形貌、粒径、物相组成及磁性能进行了表征分析。表明该磁性纳米复合物具有核壳结构。再用超声法合成了阿霉素-壳聚糖修饰的磁性纳米包合物，用紫外-可见（UV-Vis）分光光度计检测了该复合物的包封率，平均值达到46.13%。通过四唑盐（MTT）比色法证明了包合物对K150细胞的生物抑制作用。以上结果表明，该磁性纳米复合物具有良好的生物相容性和载药活性。

关键词: 壳聚糖, 盐酸阿霉素, 纳米材料, 复合材料, 四氧化三铁, 药物

Abstract:

Chitosan modified magnetic nanocomposites were synthesized by the chemical cross linking method. Physicochemical properties including the morphology, phase composition, particle size and magnetic properties were characterized by TEM, FTIR,particle size analyzer and VSM. It was proved that the modified magnetic nanocomposites had corn-shell structure. The magnetic nanocomposites with adriamycin were synthesized by the ultrasonic method. The encapsulation efficiency of magnetic nanocomposites was analyzed by UV-Vis spectrophotometry, and the average entrapment efficiency was up to 46.13%, then further determined by MTT colorimetric method proved that the inclusion compound had obvious biological inhibition of K150 cells. The results showed that the magnetic nanomaterials had good biocompatibility and drug loading activity.

Key words: chitosan, doxorubicin hydrochloride, nanomaterials, composites, magnetic oxide, pharmaceuticals

中图分类号:

O614.811

贾尚宁, 常娟娟, 李宁波, 乔洁. 核壳结构磁性纳米复合物的合成及载药性能[J]. 化工学报, 2018, 69(S1): 170-175.

JIA Shangning, CHANG Juanjuan, LI Ningbo, QIAO Jie. Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties[J]. CIESC Journal, 2018, 69(S1): 170-175.

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核壳结构磁性纳米复合物的合成及载药性能

Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties

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