多肽药物制备工艺研究进展

doi:10.11949/0438-1157.20210270

化工学报 ›› 2021, Vol. 72 ›› Issue (7): 3538-3550.DOI: 10.11949/0438-1157.20210270

多肽药物制备工艺研究进展

郑龙^1,³(),田佳鑫¹,张泽鹏¹,郭建³,朱晖³,谢慧翔³,何润泽³(),洪文晶^1,^2,³()

^1.厦门大学化学化工学院，福建厦门 361000
^2.固体表面物理化学国家重点实验室，福建厦门 361000
^3.厦门大学胜泽泰多肽制药工程与智能设备研发中心，福建厦门 361000

收稿日期:2021-02-19 修回日期:2021-05-28 出版日期:2021-07-05 发布日期:2021-07-05
通讯作者: 何润泽,洪文晶
作者简介:郑龙（1988—），男，硕士研究生，工程师，long.zheng@spacepeptides.com.cn
基金资助:
国家自然科学基金项目(21722305);国家重点研发计划项目(2017YFA0204902);厦门大学胜泽泰多肽制药工程与智能设备研发中心项目(XDHT2020018C)

Progress on pharmaceutical engineering of peptide-based drugs

ZHENG Long^1,³(),TIAN Jiaxin¹,ZHANG Zepeng¹,GUO Jian³,ZHU Hui³,XIE Huixiang³,HE Runze³(),HONG Wenjing^1,^2,³()

^1.College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361000, Fujian, China
^2.State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361000, Fujian, China
^3.Xiamen University & Space Peptides Peptide Pharmaceutical Engineering and Intelligent Equipment R&D Center, Xiamen 361000, Fujian, China

Received:2021-02-19 Revised:2021-05-28 Online:2021-07-05 Published:2021-07-05
Contact: HE Runze,HONG Wenjing

摘要/Abstract

摘要：

多肽是由氨基酸缩合连接而成的具有一定生物活性的化合物，在医药领域具有广阔的应用前景。多肽药物是现代医药研究的前沿方向，具有重要的社会价值和经济价值。综述了多肽生物合成法（天然原料提取法、酶解法、发酵法、基因重组法）和化学合成方法（液相合成法和固相合成法）的研究进展，重点综述化学合成法中的固相多肽合成工艺，介绍了反相高效液相色谱法、毛细管电泳法、离子交换色谱法、凝胶过滤色谱法、亲和层析法在多肽分离纯化中的应用情况，最后对多肽制药技术的未来发展进行展望。

关键词: 多肽, 药物, 合成, 纯化

Abstract:

Peptide is composed of amino acid through dehydration condensation, which is a compound molecule that has specific biological activity, and thus peptide-based drugs became an important direction of pharmaceutical engineering. Peptide drugs are the frontier of modern medical research and have important social and economic values. This paper reviews the research progress of peptide biosynthesis methods (natural raw material extraction, enzymatic solution, fermentation, gene recombination) and chemical synthesis methods (liquid-phase peptide synthesis and solid-phase peptide synthesis), focusing on the solid-phase peptide synthesis among chemical synthesis methods. This paper also introduces the application of reverse-phase high-performance chromatography, capillary electrophoresis, and ion exchange chromatography, gel filtration chromatography, and affinity chromatography. Finally, the future development of peptide pharmaceutical technology is prospected.

Key words: peptide, pharmaceutical, synthesis, purification

中图分类号:

TQ 464.7

郑龙, 田佳鑫, 张泽鹏, 郭建, 朱晖, 谢慧翔, 何润泽, 洪文晶. 多肽药物制备工艺研究进展[J]. 化工学报, 2021, 72(7): 3538-3550.

ZHENG Long, TIAN Jiaxin, ZHANG Zepeng, GUO Jian, ZHU Hui, XIE Huixiang, HE Runze, HONG Wenjing. Progress on pharmaceutical engineering of peptide-based drugs[J]. CIESC Journal, 2021, 72(7): 3538-3550.

图/表 7

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多肽药物制备工艺研究进展

Progress on pharmaceutical engineering of peptide-based drugs

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