Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology

doi:10.11949/j.issn.0438-1157.20151042

Abstract

Abstract:

Due to the limited amount of fossil fuels and global warming problem, bio-manufacturing based on renewable biomass has been paid more attention. In this review, the contribution of systems biology and synthetic biology in bio-manufacture of platform chemicals like organic acid such as succinate, fumarate, malate, glucaric acid, pyruvate, phenylpyruvic acid, α-ketoglutarate and other platform chemicals such as 2,5-furandicarboxylic acid are reviewed. Finally, the trends of bio-manufacture for platform chemical are prospected.

Key words: systems biology, synthetic biology, biocatalysis, biotechnology, platform chemical, bio-manufacture

摘要：

基于生物质资源的平台化学品制造,是解决目前石化资源枯竭和环境问题的重要措施,对经济社会的可持续发展具有重要意义。本文主要介绍了系统生物学和合成生物学在有机酸(琥珀酸、富马酸、L-苹果酸、葡萄糖二酸、丙酮酸、苯丙酮酸、α-酮戊二酸)以及其他平台化学品(2,5-呋喃二甲酸)生物制造中的应用,并展望了生物制造在平台化学品生产中的未来发展方向。

关键词: 系统生物学, 合成生物学, 生物催化, 生物技术, 平台化合物, 生物制造

CLC Number:

Q815

YUAN Haibo, LI Jianghua, LIU Long, DU Guocheng, CHEN Jian. Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology[J]. CIESC Journal, 2016, 67(1): 129-139.

袁海波, 李江华, 刘龙, 堵国成, 陈坚. 基于系统生物学和合成生物学的重要平台化学品生物制造的研究进展[J]. 化工学报, 2016, 67(1): 129-139.

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