Abstract: In this work a system which consists of chitosan microcores entrapped in ethylcellulose is
presented.Vitamin D2 was efficiently entrapped in chitosan microcores with spray-drying
method and was microencapsulatedby coating of ethylcellulose. The average size of chitosan
microspheres was 6.06 μm. The morphology and releaseproperties of microcapsules were
tested. The results of release in vitro showed that the microcapsule could realizesustained
release for 12 h in artificial intestinal juice.

Key words: microcapsule, chitosan, Vitamin D2

摘要： In this work a system which consists of chitosan microcores entrapped in ethylcellulose is
presented.Vitamin D2 was efficiently entrapped in chitosan microcores with spray-drying
method and was microencapsulatedby coating of ethylcellulose. The average size of chitosan
microspheres was 6.06 μm. The morphology and releaseproperties of microcapsules were
tested. The results of release in vitro showed that the microcapsule could realizesustained
release for 12 h in artificial intestinal juice.

关键词: microcapsule;chitosan;Vitamin D2