Abstract: N-isopropyl acrylamide （NIPAM） is a typical temperature-sensitive hydrogel，which has hydrophilic acylamino and hydrophobic isopropyl groups. Because of its specially reversible swelling/ shrinking properties with temperature changes，it is widely used as a new kind of intelligent material. This review mainly introduces synthesis of hydrophobically modified thermo-sensitive hydrogels. Introduction of hydrophobic monomers can improve its hydrophobic properties and increase its temperature sensitivity，so it has unique application in drug delivery，material separation and biomedical materials. There are some limitations of hydrophobically modified thermo-sensitive hydrogels in theoretical research and actual applications，so we should improve the functional groups of hydrophobic monomers，and synthesize more sensitive and environment-friendly temperature- sensitive hydrogels，expanding the applications to catalysis，water treatment，biological and chemical fields.

Key words: temperature-sensitive gels, hydrophobic, synthesis, adsorption, biomedical

摘要： N-异丙基丙烯酰胺（NIPAM）类水凝胶是典型的温敏水凝胶，通常含有亲水性酰胺基和疏水性异丙基，具有随温度变化而发生可逆溶胀/收缩的特殊性质，作为一种新型的智能材料得到广泛的应用。本文主要论述了NIPAM类疏水改性温敏水凝胶的合成，在骨架中引入疏水单体可以改善其疏水特性，同时提高其温度敏感性，使其在药物释放、物质分离及生物医用材料等领域具有独特的应用价值。目前对疏水改性温敏水凝胶的理论研究尚浅，仍需拓展其在实际方面的应用，今后可考虑改善疏水单体的官能团结构提高疏水性能，合成更具温度响应性和环境友好性的智能温敏水凝胶，拓展其在催化、水处理、生物化工等领域的广泛应用。

关键词: 温敏水凝胶, 疏水, 合成, 吸附, 生物医学