Effect of different ball milling processes on purity and particle size of β-tricalcium phosphate powders by solid-state synthesis

doi:10.11949/j.issn.0438-1157.20160418

CIESC Journal ›› 2017, Vol. 68 ›› Issue (1): 424-429.DOI: 10.11949/j.issn.0438-1157.20160418

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Effect of different ball milling processes on purity and particle size of β-tricalcium phosphate powders by solid-state synthesis

KANG Junpei^1,2, GE Ting^1,2, LIU Sa^1,2, YANG Junzhong^1,2, REN Li^1,2

1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China;
2 National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, Guangdong, China

Received:2016-04-05 Revised:2016-06-02 Online:2017-01-05 Published:2017-01-05
Contact: 10.11949/j.issn.0438-1157.20160418
Supported by:
supported by the National Natural Science Foundation of China (51273072), the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2012BAI17B02), the Science and Technology Innovation Council of Guangzhou (201508020123) and the Natural Science Foundation of Guangdong Province (2016A030313509).

不同球磨粉碎工艺对固相合成β-磷酸三钙纯度和粒度的影响

康军沛^1,2, 葛婷^1,2, 刘卅^1,2, 杨军忠^1,2, 任力^1,2

1 华南理工大学材料科学与工程学院, 广东广州 510640;
2 华南理工大学国家人体组织功能重建技术研究中心, 广东广州 510006

通讯作者: 任力
基金资助:
国家自然科学基金项目（51273072）；十二五国家科技支撑计划项目（2012BAI17B02）；广州市科技计划项目（201508020123）；广东省自然科学基金项目（2016A030313509）。

Abstract

Abstract:

β-Tricalcium phosphate powders were prepared by nano ball milling and ultrasonic stirring process and compared with conventional process in this research.The purity and particle size of β-TCP powders were investigated by differential scanning calorimetry(DSC), X-ray diffraction(XRD), Fourier transform infrared spectroscope(FTIR), nanoparticle test, scanning electronic microscopy(SEM), transmission electron microscope(TEM) and X-ray fluorescence spectrum(XRF).The results reveal that the purity of β-TCP powders prepared by the nano ball milling and ultrasonic stirring process can reach over 97%, and the powders average particle size is 666 nm, with high purity and uniform particle size.Moreover, the raw materials with small particle size and good dispersion can be processed through nano ball milling.This process has great potential in the synthesis of inorganic powders by solid-state synthesis.

Key words: nano ball milling, ultrasonic stirring, solid-state, synthesis, powder technology, size distribution

摘要：

采用纳米球磨-超声搅拌工艺制备了β-磷酸三钙粉体，并与传统固相合成工艺进行了对比研究。采用差示扫描量热（DSC）、X射线衍射（XRD）、红外（FTIR）、纳米粒度测试、扫描电镜（SEM）、透射电镜（TEM）及X射线荧光光谱（XRF）等手段对两种工艺所制备粉体进行了纯度和粒度表征。结果表明：相比传统工艺，经过纳米球磨-超声搅拌工艺制备出的β-TCP粉体纯度可达97%以上，平均粒径为666 nm。粉体的纯度高、粒径分布更均匀。同时，纳米球磨加工后的原料平均粒度更小，分散性更好。该工艺有望用于粉体材料的固相合成。

关键词: 纳米球磨, 超声搅拌, 固相, 合成, 粉体技术, 粒度分布

CLC Number:

O611.4

KANG Junpei, GE Ting, LIU Sa, YANG Junzhong, REN Li. Effect of different ball milling processes on purity and particle size of β-tricalcium phosphate powders by solid-state synthesis[J]. CIESC Journal, 2017, 68(1): 424-429.

康军沛, 葛婷, 刘卅, 杨军忠, 任力. 不同球磨粉碎工艺对固相合成β-磷酸三钙纯度和粒度的影响[J]. 化工学报, 2017, 68(1): 424-429.

References 20

[1]	黄占杰. 磷酸钙陶瓷生物降解研究的进展[J]. 功能材料, 1997, 28(1):1-4. HUANG Z J. Development of biodegradable calcium phosphate ceramics[J]. Journal of Functional Materials, 1997, 28(1):1-4.
[2]	OPRITA E I, MOLDOVAN L, CRACIUNESCU O, et al. In vitro behaviour of osteoblast cells seeded into a COL/β-TCP composite scaffold[J]. Central European Journal of Biology, 2008, 3(1):31-37.
[3]	LIU X, MA P X. Polymeric scaffolds for bone tissue engineering[J]. Annals of Biomedical Engineering, 2004, 32(3):477-486.
[4]	李世普. 生物医用材料导论[M]. 武汉:武汉工业大学出版社, 2000:108-109, 113-116. LI S P. Introduction of Biomedical Material[M]. Wuhan:Wuhan University of Technology Press, 2000:108-109,113-116.
[5]	FRANKENBURG E P, GODSTEIN S A, BANER T W, et al. Biomechanical and histological evaluation of a calcium phosphate cement[J]. J. Bone. Joint. Surg. Am., 1998, 80(8):1112-1124.
[6]	OSAKA A, MIURA R, TAEUCHI K, et al. Calcium apatite prepared from calcium hydroxide and orthophosphoric acid[J]. J. Mater. Sci., 1991, 2(1):51-55.
[7]	JATCHO M, BOLEN C H. Hydroxyapatite synthesis and characterization in dense polycrystalline form[J]. J. Mater. Sci., 1976, 11(2):227-235.
[8]	徐子颉, 马超, 王芬芬, 等. 磷酸一氢钙在甲醇中转化为β-磷酸三钙纳米晶的研究[J]. 无机化学学报, 2012, 28(2):215-220. XU Z J, MA C, WANG F F, et al. Crystal transformation from CMHP to β-TCP in methanol[J]. Chinese Journal of Inorganic Chemistry, 2012, 28(2):215-220.
[9]	何毅, 刘孝波, 杨德娟, 等. 纳米级β-磷酸钙的合成[J]. 合成化学, 2000, 8(2):88-99. HE Y, LIU X B, YANG D J, et al. The synthesis of nanosized β-tricalcium phosphate[J].Chinses Journal of Synthetic Chemistry, 2000, 8(2):88-99.
[10]	张大海, 阚红华, 翁文剑, 等. 醇化合物法合成钙磷酸盐[J]. 硅酸盐通报, 1998, 6:9-12. ZHANG D H, KAN H H, WENG W J, et al. Calcium phosphates synthesized by alkoxides[J]. Bulletin of the Chinese Ceramic Society, 1998, 6:9-12.
[11]	TAO J, JIANG W, ZHAI H, et al. Structural components and anisotropic dissolution behaviors in one hexagonal single crystal of β-tricalcium phosphate[J]. Crystal Growth & Design, 2008, 8(7):2227-2234.
[12]	BOW J S, LIOU S C, CHEN S Y. Structural characterization of room-temperature synthesized nano-sized β-tricalcium phosphate[J]. Biomaterials, 2004, 25(16):3155-3161.
[13]	FAMERY R, RICHARED N, BOCH P. Preparation of α-and β-tricalcium phosphate ceramics, with and without magnesium addition[J]. Ceram. Int., 1994, 20:327-336.
[14]	GROSS K A, BERZINA L, CIMDINS R, et al. Calcium phosphate bioceramics research in Latvia[J]. Ceramics International, 1999, 25(3):231-237.
[15]	闫玉华, 樊东辉. β-TCP多孔陶瓷药物载体的制备与微观结构[J]. 武汉工业大学学报, 1995, (4):106-108. YAN Y H, FAN D H. Preparing and microstructure of β-TCP porous ceramic drug carrier[J]. Journal of Wuhan University of Technology, 1995, (4):106-108.
[16]	CHOU J, GREEN D W, SINGH K, et al. Adipose stem cell coating of biomimetic β-TCP macrospheres by use of laboratory centrifuge[J]. BioResearch Open Access, 2013, 2(1):67-71.
[17]	HATTORI T, IWADATE Y. Hydrothermal preparation of calcium hy droxyapalite powders[J]. J. Am. Ceram. Soc., 1990, 73(6):1803-1805.
[18]	张士华. β-磷酸三钙粉末和多孔β-磷酸三钙生物陶瓷的研制[D]. 安徽:合肥工业大学, 2002. ZHANG S H. Preparation and properties of β-tricalcium phosphate powder and its porous bioceramic[D]. Anhui:Hefei University of Technology, 2002.
[19]	PAIK J G, LEE M J, HYUN S H. Reaction kinetics and formation mechanism of magnesium ferrites[J]. Thermochimica Acta, 2005, 425(1/2):131-136.
[20]	张丽. 湿固相机械球磨法制备超细二氧化铈粉末[D]. 四川:西华大学, 2008. ZHANG L. Preparation of supferfine CeO2 by wet solid phase mechanochemical method[D]. Sichuan:Xihua University, 2008.

Effect of different ball milling processes on purity and particle size of β-tricalcium phosphate powders by solid-state synthesis

不同球磨粉碎工艺对固相合成β-磷酸三钙纯度和粒度的影响

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