Research advances of drug-drug co-crystals

doi:10.11949/0438-1157.20201139

Abstract

Abstract:

Combination drugs show the potential advantages of reducing drug dosage, toxicity, drug resistance and improving therapeutic effect in clinical treatment. As a new method of combined medicine, drug-drug co-crystals have achieved drug efficiency at the molecular level. It is expected to solve the problems of significant solubility difference, incompatibility and poor stability between drug ingredients. This paper reviews the concept and advantages of drug-drug co-crystals, the formation, dissolution and metabolism mechanisms of drug-drug co-crystals. How to design and predict drug-drug co-crystals from both theoretical and experimental aspects is introduced. Finally, the problems of drug-drug co-crystals that need to be solved are summarized, and the future development direction of drug-drug co-crystals is prospected.

Key words: drug-drug co-crystals, formation mechanism, dissolution, metabolism, design, prediction

摘要：

联合用药在临床治疗中显示出降低药物剂量、毒性、耐药性以及提高治疗效果的潜在优势。药物-药物共晶作为联合用药的一种新方法，在分子水平上实现了药物的联合，有望解决联合用药中存在的原料药之间的溶解度差异大、不相容和稳定性差等问题，近几年来引起了研究人员的广泛关注。本文综述了药物-药物共晶的概念和优势，药物-药物共晶的形成、溶解和代谢机理，以及药物-药物共晶的设计和预测方法，最后总结了药物-药物共晶领域尚需解决的问题，并对未来的发展方向进行了展望。

关键词: 药物-药物共晶, 形成机理, 溶解, 代谢, 设计, 预测

CLC Number:

TQ 460.1

SUN Jingjing, JIA Lina, LIN Bo, WANG Yan, GONG Junbo. Research advances of drug-drug co-crystals[J]. CIESC Journal, 2021, 72(2): 828-840.

孙晶晶, 贾丽娜, 林波, 王艳, 龚俊波. 药物-药物共晶的研究进展[J]. 化工学报, 2021, 72(2): 828-840.

Figures/Tables 7

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