Synthesis of gramine using acidic ionic liquid as catalyst

doi:10.11949/j.issn.0438-1157.20150160

Abstract

Abstract: Acidic ionic liquid 1- butyl -3- methyl imidazole hydrogen sulfate ([bmim]⁺HSO₄^-) was prepared by using 1- methyl imidazole as a starting material through alkylation by n-butyl bromide and anion exchange with H₂SO₄. The synthesis of gramine from indole was investigated by employing the ionic liquid as catalyst with the yield of 81.6%, and the catalyst can be used continuously 4 times with keeping the yield essentially unchanged. The results demonstrated that the ionic liquid catalyst has excellent performance of environmental friendly, and the catalytic activity is more acceptable, reusable than the proton acid catalyst.

Key words: ionic liquid, gramine, catalysis, synthesis

摘要： 以1-甲基咪唑为原料, 经1-溴丁烷N-烷基化, 再与H₂SO₄进行阴离子交换得到酸性离子液体1-丁基-3-甲基咪唑硫酸氢盐([bmim]⁺ HSO₄^-), 并以此为催化剂研究了以吲哚为原料的芦竹碱的合成, 收率可达81.6%, 催化剂连续使用4次收率基本维持不变。研究结果表明, 在芦竹碱的合成反应中离子液体催化剂相比质子酸催化, 具有环境友好, 催化活性可接受, 可重复利用的优良性能。

关键词: 离子液体, 芦竹碱, 催化, 合成

CLC Number:

TQ0324

ZHANG Die, PENG Xiaoming, LIU Bo, GUO Xiaoyan, CAO Qianming, CHAO Jianping. Synthesis of gramine using acidic ionic liquid as catalyst[J]. , 2015, 66(S1): 192-196.

张蝶, 彭效明, 刘博, 郭晓燕, 曹前明, 晁建平. 以酸性离子液体为催化剂的芦竹碱合成[J]. CIESC Journal, 2015, 66(S1): 192-196.

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