Robust optimization of process parameters of simulated moving bed based on equilibrium theory

doi:10.11949/0438-1157.20211281

Abstract

Abstract:

In the actual working process of the simulated moving bed, due to the influence of factors such as the feed concentration and temperature change and the inconsistent packing of the chromatographic column, the separation performance under the operation of the initial process parameters may be reduced. The paper first analyzed the mechanism model of the simulated moving bed. Then based on the equilibrium theory of chromatographic separation, a new process parameters point is obtained by using the orthogonal collocation on finite elements method. Finally, taking the separation of fructose syrup as the object, the optimized process parameters under disturbed operation were obtained by the proposed method. The results show that the pass rate of fructose purity increased from 81% to 99%, which proved that the method has good robustness.

Key words: simulated moving bed, chromatography, separation, orthogonal collocation on finite elements, equilibrium theory, robust, optimal design

摘要：

在模拟移动床的实际工作过程中，由于进料浓度和温度变化以及色谱柱填充不一致等因素影响，初始工艺参数作业下的分离性能可能会出现下降。首先对模拟移动床的机理模型进行了分析；然后在色谱分离平衡理论的基础上，使用有限元正交配置法求解模型得到新的工艺参数点；最后以果葡糖浆组分分离为对象，使用所提方法求解有扰动作用时的优化工艺参数，结果显示果糖纯度的合格率从81%提高到99%，证明其具有良好的鲁棒性。

关键词: 模拟移动床, 色谱, 分离, 有限元正交配置法, 平衡理论, 鲁棒, 优化设计

CLC Number:

TQ 028.8

Peng WEI, Jun CHEN, Zhiguo WANG, Fei LIU. Robust optimization of process parameters of simulated moving bed based on equilibrium theory[J]. CIESC Journal, 2022, 73(2): 792-800.

魏朋, 陈珺, 王志国, 刘飞. 基于平衡理论的模拟移动床工艺参数鲁棒寻优[J]. 化工学报, 2022, 73(2): 792-800.

Figures/Tables 11

Fig.1 Schematic diagram of conventional SMB operation

Fig.2 Orthogonal collocation on finite element

Fig.3 Different separation regions of the system described by linear adsorption isotherms on the m2-m3 plane

Fig.4 Flow chart of optimizing solution for simulated moving bed

Table 1 Model parameters and process parameters of simulated moving bed

模型参数		工艺参数
柱分布结构	2-2-2-2	A的进料浓度	0.5 g/ml
组分数	2	B的进料浓度	0.5 g/ml
柱长	53.6 cm	进料液流量	0.0200 ml/s
柱直径	2.6 cm	洗脱液流量	0.0414 ml/s
空隙率	0.38	提取液流量	0.0348 ml/s
轴向扩散系数	0.0381 cm²/s	提余液流量	0.0266 ml/s
A的Henry系数	0.54	循环液流量	0.0981 ml/s
B的Henry系数	0.28	切换时间	1552 s

Fig.5 Running process of the simulate moving bed

Fig.6 Steady-state concentration distribution of the simulate moving bed

Fig.7 The product purity and recovery rate obtained by running 300 sets of normal distribution values ??(L,ε) generated under the random disturbance action under the initial process parameters

Fig.8 Distribution of the flow ratio corresponding to the sample point (L,ε) on the m2-m3 plane at the initial process parameters

Fig.9 Distribution of the flow ratio corresponding to the sample point (L,ε) on the m2-m3 plane at the robust process parameters

Fig.10 The product purity and recovery rate obtained by running 300 sets of normal distribution values (L,ε) generated under the random disturbance action under the robust process parameters

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