化工学报 ›› 2020, Vol. 71 ›› Issue (9): 4071-4101.DOI: 10.11949/0438-1157.20200495
收稿日期:
2020-05-06
修回日期:
2020-08-08
出版日期:
2020-09-05
发布日期:
2020-09-05
通讯作者:
梁建华
作者简介:
范炳芝(1995—),女,硕士研究生,基金资助:
Bingzhi FAN(),Yixin WANG(),Xiaotian LIAN,Weisong XIE,Yang YU,Jianhua LIANG()
Received:
2020-05-06
Revised:
2020-08-08
Online:
2020-09-05
Published:
2020-09-05
Contact:
Jianhua LIANG
摘要:
三萜类化合物广泛存在于自然界中,因其具有抗肿瘤、抗病毒、抗菌、抗炎和免疫调节等多种药理活性而受到广泛关注。而天然三萜中的齐墩果酸、熊果酸、甘草酸和白桦酸等化合物都表现出较好的抗病毒活性。本文综述了以四环三萜和五环三萜为主的三萜类化合物及其衍生物在抗病毒活性方面的研究进展,重点介绍了其抗艾滋病毒、抗流感病毒、抗冠状病毒和抗乙肝/丙肝病毒的构效关系及其作用机制,以期为设计和开发新型的抗病毒分子结构提供参考。
中图分类号:
范炳芝, 王一鑫, 廉霄甜, 谢维松, 于洋, 梁建华. 三萜类化合物抗病毒的构效关系及其作用机制研究进展[J]. 化工学报, 2020, 71(9): 4071-4101.
Bingzhi FAN, Yixin WANG, Xiaotian LIAN, Weisong XIE, Yang YU, Jianhua LIANG. Structure-activity relationships and mechanisms of triterpenoids against virus[J]. CIESC Journal, 2020, 71(9): 4071-4101.
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