用于伤口敷料的水凝胶电刺激释药性能

doi:10.11949/0438-1157.20240286

摘要/Abstract

摘要：

水凝胶是一种具有三维空间网络结构的高分子材料，可以作为理想的新型伤口敷料，但在自然释放条件下水凝胶伤口敷料释药速率缓慢。为了促进伤口愈合，以羧甲基壳聚糖和海藻酸钠为基体，在水凝胶中加入了导电剂聚吡咯和抗菌药物盐酸环丙沙星，制备了载药水凝胶，构筑了水凝胶电刺激释药装置。研究了不同聚吡咯含量下水凝胶的溶胀性能、力学性能和导电性能的变化，以及在电刺激条件下盐酸环丙沙星药物释放规律。研究表明：聚吡咯与基体投料比为0.4时，水凝胶在理化性能和力学性能上综合表现最佳，更适合用于伤口敷料。电刺激作用可以有效加速水凝胶内部的药物释放，对于伤口的治疗具有积极的意义。

关键词: 羧甲基壳聚糖, 水凝胶, 伤口敷料, 药物, 扩散, 凝胶

Abstract:

Hydrogel is a polymer material with a three-dimensional network structure and can be used as an ideal new wound dressing. However, the releasing rate of hydrogel wound dressing is slow under natural conditions. To promote wound healing, the hydrogel is prepared by using carboxymethyl chitosan and sodium alginate as matrix, and polypyrrole as the conductive agent. The ciprofloxacin hydrochloride is added into the hydrogel as the antibacterial drug. The drug releasing device driven by the electrostimulation is constructed. The impacts of polypyrrole content on the swelling property, mechanical property and electrical conductivity, and the releasing property of ciprofloxacin hydrochloride under electrical stimulation are studied. When the ratio of polypyrrole to the matrix is 0.4, the hydrogel shows the optimized comprehensive performance in physicochemical property and mechanical property, and is more suitable for wound dressing. The electrical stimulation can effectively accelerate the releasing rate of drugs interior the hydrogel, and benefit the treatment of wounds.

Key words: carboxymethyl chitosan, hydrogel, wound dressing, pharmaceuticals, diffusion, gels

中图分类号:

R 313

贾娟, 杨扬, 朱恂, 叶丁丁, 陈蓉, 廖强. 用于伤口敷料的水凝胶电刺激释药性能[J]. 化工学报, 2024, 75(7): 2700-2708.

Juan JIA, Yang YANG, Xun ZHU, Dingding YE, Rong CHEN, Qiang LIAO. Hydrogel-based drug releasing system with external electricity stimulation for wound dressing[J]. CIESC Journal, 2024, 75(7): 2700-2708.

图/表 12

图1 SA/CMCS/PPy水凝胶

Fig.1 SA/CMCS/PPy hydrogel

图2 SA/CMCS/PPy水凝胶制备流程图

Fig.2 Schematic of preparation process of SA/CMCS/PPy hydrogel

图3 SA/CMCS/PPy导电水凝胶的SEM图（a）；水凝胶不同位置的聚吡咯形貌（b）

Fig.3 SEM images of SA/CMCS/PPy conducting hydrogels (a); SEM images of PPy at different positions of hydrogels (b)

图4 CIP、SA/CMCS/PPy水凝胶和SA/CMCS/PPy/CIP水凝胶的FT-IR光谱图

Fig.4 FT-IR spectra of CIP, SA/CMCS/PPy hydrogels and SA/CMCS/PPy/CIP hydrogels

图5 不同PPy投料比水凝胶孔隙率

Fig.5 Hydrogel porosity with different PPy mass ratio

图6 不同PPy投料比水凝胶的溶胀率

Fig.6 Swelling ratio of hydrogels with different PPy mass ratio

图7 不同PPy投料比水凝胶失水率变化

Fig.7 Variation of hydrogel water loss rate at different PPy mass ratio

图8 不同PPy投料比水凝胶的电导率变化曲线

Fig.8 Conductivity curves of hydrogels with different PPy mass ratio

图9 不同PPy投料比水凝胶的最大抗拉伸强度与最大伸长率

Fig.9 The maximum tensile strength and maximum elongation of hydrogels

图10 不同PPy投料比水凝胶的抗压缩强度随压缩率的变化（a）；不同PPy投料比水凝胶的最大抗压缩强度的对比（b）

Fig.10 The compression strength curves of hydrogels with different PPy mass ratio as a function of compression ratio (a); Comparison of the maximum compressive strength of hydrogels with different PPy mass ratio (b)

图11 盐酸环丙沙星的标准曲线

Fig.11 Standard curve of ciprofloxacin hydrochloride

图12 盐酸环丙沙星的药物释放曲线

Fig.12 Drug release curve of ciprofloxacin hydrochloride

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