酸化凹凸棒石/海藻酸复合材料的制备及其缓释性能

doi:10.3969/j.issn.0438-1157.2014.11.059

化工学报 ›› 2014, Vol. 65 ›› Issue (11): 4627-4632.DOI: 10.3969/j.issn.0438-1157.2014.11.059

• 材料化学工程与纳米技术 • 上一篇下一篇

酸化凹凸棒石/海藻酸复合材料的制备及其缓释性能

吴洁, 丁师杰, 陈静, 蒋金龙, 王军军

淮阴工学院生命科学与化学工程学院, 江苏省凹土资源利用重点实验室, 江苏淮安 223003

收稿日期:2014-04-24 修回日期:2014-06-27 出版日期:2014-11-05 发布日期:2014-11-05
通讯作者: 吴洁
基金资助:
江苏省教育厅高校科研成果产业化推进资助项目(JHB2012-57);国家自然科学基金项目(21174046,51174096).

Preparation and sustained release properties of acidified-attapulgite/alginate composite material

WU Jie, DING Shijie, CHEN Jing, JIANG Jinlong, WANG Junjun

Department of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huai'an 223003, Jiangsu, China

Received:2014-04-24 Revised:2014-06-27 Online:2014-11-05 Published:2014-11-05
Supported by:
supported by the College Industrialization Project of Jiangsu Province (JHB2012-57) and the National Natural Science Foundation of China (21174046, 51174096).

摘要/Abstract

摘要： 以海藻酸钠 (SA) 和酸化凹凸棒石 (H⁺-ATP) 为原料,运用溶液共混法制备了一种具有优良缓释性能的复合材料,并以其为基质材料制备了双氯芬酸钠 (DS) 缓释片.利用SEM、FTIR和XRD对复合材料形貌和结构进行了表征,考察了酸改性剂浓度、H⁺-ATP用量和复合时间对复合材料缓释性能的影响,以获得最佳复合工艺.结果表明,当用12 mol·L^-1盐酸酸化的ATP量占复合物总量60%时,复合缓释片在体外模拟肠液中缓释性能最佳.与单一海藻酸缓释片相比,复合缓释片2 h的累积释放率由42.6%下降到23.7%,有效改善了"突释"效应.释放动力学研究表明,复合缓释片的释药行为可以用Ritger-Peppas方程很好地拟合,释药速率受骨架溶蚀和药物扩散双重控制.H⁺-ATP的加入显著改善了海藻酸的缓释性能.

关键词: 酸化凹凸棒石, 海藻酸钠, 复合材料, 缓释性能, 共混, 载体

Abstract: A composite material with improved sustained release properties, based on hybridization of sodium alginate (SA) and acidified-attapulgite (H⁺-ATP), was prepared by solution mixing and was developed for drug carrier. Diclofenac sodium (DS) was selected as the model drug to obtain release data from the composite-based matrix tablets in phosphate buffer solution (PBS) in vitro. The morphology and structure of the composite were characterized by FTIR, SEM and XRD. The effect of content of acid modifier, H⁺-ATP content and mixing time on the slow release properties of the composite were investigated to obtain optimum process condition. The composite with 60% H⁺-ATP treated by 12 mol·L^-1 HCl exhibited perfect release properties. Compared with pure alginate tablets, the burst release of 42.6 % in 2 h decreased to 23.7% for the prepared composite. The drug release process of the composite was better fitted by the Ritger-Peppas model and the rate of drug release was governed by both diffusion and swelling mode. The introduced H⁺-ATP improved the release properties of alginate significantly.

Key words: acidified-attapulgite, sodium alginate, composites, sustained release properties, mixing, carrier

中图分类号:

TQ316.6

吴洁, 丁师杰, 陈静, 蒋金龙, 王军军. 酸化凹凸棒石/海藻酸复合材料的制备及其缓释性能[J]. 化工学报, 2014, 65(11): 4627-4632.

WU Jie, DING Shijie, CHEN Jing, JIANG Jinlong, WANG Junjun. Preparation and sustained release properties of acidified-attapulgite/alginate composite material[J]. CIESC Journal, 2014, 65(11): 4627-4632.

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酸化凹凸棒石/海藻酸复合材料的制备及其缓释性能

Preparation and sustained release properties of acidified-attapulgite/alginate composite material

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