关键词:

石英晶体微天平（介微称重技术）, 超临界流体掺杂, 药物, 聚合物, 分配

Abstract:

A high-pressure quartz crystal microbalance (QCM) apparatus was developed to investigate the absorption of carbon dioxide in two glassy polymer films—polystyrene (PS) and polyvinylpyrrolidone (PVP) at 40℃ and pressure up to 9.0 MPa.PVP was shown to have better CO₂ absorption and chosen as the representative for supercritical impregnation of two model drugs—o-aminobenzoic acid and ibuprofen at 40℃ and pressure up to 8.0 MPa.It was found that the two impregnants were embedded into the polymer with a partition coefficient as high as 10⁴ order of magnitude.Since the sub-microweighing technique established and utilized in this study was simple, convenient and accurate, it was believed that the technique could have wide and effective applications in supercritical impregnation processes.

Key words:

石英晶体微天平（介微称重技术）, 超临界流体掺杂, 药物, 聚合物, 分配