玉米醇溶蛋白用作药物输送系统载体的研究进展

doi:10.3969/j.issn.0438-1157.2013.10.002

摘要/Abstract

摘要： 玉米醇溶蛋白(Zein)是一种天然可食性植物大分子,具有可再生性、无毒性、两亲性及良好的生物相容性和生物可降解性,可通过自组装形成微球或纳米粒。近年来,Zein用作药物输送系统(drug delivery system,DDS)载体材料成为研究热点,可通过Zein的自组装特性将药物包载在其内部获得Zein-DDS微粒。本文简述了Zein的特性及其作为DDS载体的优势,总结了Zein-DDS的制备方法、性能及Zein的修饰改性研究进展,指出Zein具有较强的疏水性和抗胃酸分解特性,Zein-DDS可有效地提高药物稳定性、延缓药物释放及增强药物靶向性。因此,Zein用作DDS的载体具有广阔的应用前景,今后的研究工作将会在拓宽研究领域、改进制备方法及Zein的修饰改性等方面展开。

关键词: 玉米醇溶蛋白, 自组装, 药物输送系统, 载体, 控制释放, 修饰

Abstract: Zein,one of the natural and edible biomacromolecules in plant,is renewable,nontoxic,biocompatible and biodegradable.Zein is capable of self-assembly into microspheres or nanoparticles because of its amphipathicity,and is an attractive drug carrier and has a promising prospect for drug delivery systems(DDS).Recently,the study of using Zein as carrier for drug delivery systems has become popular.The properties and advantages of Zein used as DDS carriers were introduced at first in this paper.Then,methods for the preparation of Zein-DDS and the characteristics of Zein-DDS were reviewed in detail.Moreover,the researches on the modification of Zein for carrier were also presented.In summary,Zein has a strong hydrophobicity and a good resistance to the digestive processes of stomach. Therefore,Zein-DDS can improve the stability of drugs,control and prolong drug release,and enhance drug targeting effectively.The future orientations could focus on broadening research fields,improving preparation methods and developing modification of Zein.

Key words: Zein, self-assembly, drug delivery system, carrier, controlled release, modification

中图分类号:

TQ469

刘贵金, 汪红娣, 江燕斌. 玉米醇溶蛋白用作药物输送系统载体的研究进展[J]. 化工学报, 2013, 64(10): 3493-3504.

LIU Guijin, WANG Hongdi, JIANG Yanbin. Research progress of Zein as carrier for drug delivery systems[J]. CIESC Journal, 2013, 64(10): 3493-3504.

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