关键词: 茚酮, 合成, 环化法, 还原, 光化学

Abstract: Indanones are found in a large number of natural products. Indanones possess a variety of physiological activity and are utilized as important intermediates in organic synthesis of medicines，pesticides and dyes. The cyclization method for the synthesis of indanone is discussed，and intramolecular Friedel-Crafts cyclization is the classical process of indanone synthesis. The advantages of this method are mature technology，simple post-processing and easy industrialization; its disadvantages are a large number of scrap liquid including aluminium，which pollute the environment. Meanwhile，the recent methods （e.g. rearrangement and photochemical method） for the synthesis of indanones are reviewed. Compared with the classical synthesis methods，the recent methods have advantages of mild conditions，fewer steps，and high purity of indanones. But the new methods are not easy to achieve industrialization due to limitation of raw materials and other conditions. The focus of indanone synthesis in the future is to develop green processes of atom economy and easy industrialization.

Key words: indanone, synthesis, cyclization method, reduction, photochemistry