关键词: 苯酚, 甲醇, 金属氧化物, 烷基化

Abstract: Recent progress in the metallic oxides catalysts for vapour phase ortho-selective C-alkylation of phenol with methanol was reviewed. Different catalysts systems as well as synthesis processes for vapor phase ortho-selective C-alkylation of phenol with methanol that yields o-cresol and 2,6-xylenol were compared，especially，the research progress in a continuous flow fixed-bed reactor over the metallic oxides catalysts was discussed. Furthermore，the activities of single component and multiple component metallic oxides catalysts toward C-alkylation of phenol were compared，and the relationship between the acidic-basic properties of the catalysts and the catalytic performance were clarified. The deactivation and the possible reaction mechanism were also discussed in detail. Finally，the difficulties and challenges of the novel environment-benign and high-efficiency catalysts were discussed，meanwhile the recent research hot points of anometer catalyst and biomass catalyst were proposed.

Key words: phenol, methanol, metallic oxide, alkylation