关键词: 聚乙二醇, 刷状共聚物, 合成, 药物输送性能, 纳米材料, 表面

Abstract: Brush copolymers with poly(ethylene glycol) (PEG) as side chains have received wide attentions due to their unique properties and potential applications. In this article，the synthesis strategies，including “grafting through” and “grafting onto”，their speci?c advantages and limitations are reviewed，with an emphasis on brush PEG copolymers based on biodegradable materials，such as polyesters. In each strategy，various polymerization techniques，such as ionic polymerization，radical polymerization，ring opening polymerization and their compatible partner various coupling reactions，are employed. Meanwhile，the surface morphologies of the micelles built from linear PEG copolymers and brush PEG copolymers are illustrated in this article，and the effects of the architecture of PEG brush on the formed nanoparticles’ properties in drug delivery are briefly discussed. Well-de?ned brush PEG structure can prolong circulation times，resulting in improvement in drug efficacy. However，the effective synthetic methods as well as the micelles’ in vivo and in vitro properties still need ongoing and further researches.

Key words: poly(ethylene glycol), brush copolymers, synthesis, drug delivery properties, nanomaterials, surface