Abstract:

The chemoenzymatic cascade catalysis combines the broad reactivity of chemical catalysis with the high selectivity of biocatalysis, and is an effective way to asymmetrically synthesize high value-added chiral compounds. However, the incompatibilities between the chemo- and biocatalysts as well as between their respective reaction conditions greatly restricted the development of this field. The design of feasible approaches to solve these problems can achieve the compatibility and complementary advantages of the two catalytic categories, thus making the chemoenzymatic cascade catalytic reactions more widely applied. In this review, the recent progress in developing strategies to overcome the incompatibility between chemical catalysis and enzymatic catalysis, such as temporal separation, spatial separation and integrated catalysts, is reviewed. The applications of chemoenzymatic cascade catalysis in dynamic kinetic resolution of chiral compounds and synthesis of chiral drugs are also introduced. Finally, the future limitations and the development trends of this field are prospected.

Key words: chemical catalysis, biocatalysis, chemoenzymatic cascade reaction, synthesis, immobilization, compatibility

摘要：

化学-酶级联催化结合了化学催化的广泛反应性与生物催化的高选择性，是不对称合成高附加值手性化合物的有效途径。然而，化学催化剂和酶之间以及它们反应条件之间的不相容性极大地限制了这一领域的发展。因此设计可行的方法解决这些问题，实现两种催化范畴的兼容和优势互补，将使化学-酶级联催化反应得到更广泛的应用。综述了近年来克服化学催化与酶催化不相容性所采取的一些策略以及相关的研究进展，如时间分隔、空间分隔和集成催化剂等，并介绍了化学-酶级联催化在手性化合物动态动力学拆分及手性药物合成方面的应用，最后展望了该领域未来的局限性和发展趋势。

关键词: 化学催化, 生物催化, 化学-酶级联反应, 合成, 固定化, 相容性