CIESC Journal ›› 2024, Vol. 75 ›› Issue (4): 1455-1468.DOI: 10.11949/0438-1157.20231328

• Reviews and monographs • Previous Articles     Next Articles

Controlled preparation of droplets, particles and capsules by microfluidics and their applications

Xiaoying JI1,2(), Yuan ZHENG3, Xiaopeng LI1,2, Zhen YANG1,2, Wei ZHANG4, Shirui QIU4, Qianying ZHANG1,2, Canghai LUO3, Dongpeng SUN3, Dong CHEN3(), Dongliang LI1,2()   

  1. 1.Cigar Fermentation Technology Key Laboratory of China Tobacco, China Tobacco Sichuan Industrial Co. , Ltd. , Chengdu 610100, Sichuan, China
    2.Industrial Efficient Utilization of Domestic Cigar Tobacco Key Laboratory of Sichuan Province, China Tobacco Sichuan Industrial Co. , Ltd. , Chengdu 610100, Sichuan, China
    3.College of Energy Engineering, Zhejiang University, Hangzhou 310029, Zhejiang, China
    4.The Greatwall Cigar Factory, China Tobacco Sichuan Industrial Co. , Ltd. , Shifang 618400, Sichuan, China
  • Received:2023-12-13 Revised:2024-02-02 Online:2024-06-06 Published:2024-04-25
  • Contact: Dong CHEN, Dongliang LI

微流控可控制备液滴、颗粒和胶囊及其应用

吉笑盈1,2(), 郑园3, 李晓鹏1,2, 杨振1,2, 张维4, 邱诗蕊4, 张倩颖1,2, 罗沧海3, 孙东鹏3, 陈东3(), 李东亮1,2()   

  1. 1.四川中烟工业有限责任公司烟草行业雪茄发酵工艺重点实验室,四川 成都 610100
    2.四川中烟工业有限责任公司 厅市共建国产雪茄烟叶工业高效利用重点实验室,四川 成都 610100
    3.浙江大学能源工程学院,浙江 杭州 310029
    4.四川中烟工业有限责任公司长城雪茄厂,四川 什邡 618400
  • 通讯作者: 陈东,李东亮
  • 作者简介:吉笑盈(1990—),女,博士,工程师,jixychen@163.com
  • 基金资助:
    地市级科研项目(20202303BA530);国家重点研发计划项目(2021YFC3001100)

Abstract:

Microfluidics has unique advantages in the controlled preparation of droplets, particles and capsules. Microfluidics could precisely control the size, distribution, structure and composition of droplets, particles and capsules, which are widely used in the field of biomedicine, food and cosmetics. This review comprehensively summarizes the device design, preparation strategy and industrial application for the controlled preparation of droplets, particles and capsules by microfluidics. In addition, the application of multiphase flow numerical simulation of the preparation process of droplets, particles and capsules and the optimization of experimental parameters are also highlighted, as well as the parallel scale-up strategy of microfluidic devices to achieve mass production of droplets, particles and capsules. This review will provide an important guide for the preparation and application of droplets, particles and capsules.

Key words: microfluidics, droplet, particle, capsule, numerical simulation, parallel scale-up, microchannel

摘要:

微流控技术在可控制备液滴、颗粒和胶囊方面具有独特优势,能够精确控制液滴、颗粒和胶囊的粒径大小、尺寸分布、形貌结构和材料组成,在生物医药、食品、护肤品等领域具有广泛应用。详细总结了微流控技术可控制备液滴、颗粒和胶囊所用的器件设计、工艺策略及其相关应用。此外,还重点介绍了多相流数值模拟在液滴、颗粒和胶囊制备过程和优化实验参数中的应用,以及微流控器件实现液滴、颗粒和胶囊量产的平行放大策略。将为液滴、颗粒和胶囊的制备和应用提供重要指导。

关键词: 微流控, 液滴, 颗粒, 胶囊, 数值模拟, 平行放大, 微通道

CLC Number: