Core technology in chemicals green manufacturing: synthetic biology

doi:10.11949/j.issn.0438-1157.20151033

Abstract

Abstract:

Synthetic biology is the engineering of biology. Because it breaks the boundary of inanimate chemicals and life matter, and also promotes life science from understanding to creating, the synthetic biology has played a disruptive role in the development of science and technology, leading to great changes in chemical green manufacturing. Synthetic biology, as a core technology in chemical green manufacturing, mainly focuses on the design and optimization from raw materials to chassis and then the whole process. From the raw materials diversity, chemicals production and chassis selection aspects, the key role of synthetic biology in the chemical green manufacturing process, and also systematically elaborated the design and construction of artificial systems were summarized in this paper. In terms of feedstock, host cell and process, three aspects of outlook on how to develop synthetic biology to promote chemicals green manufacturing in the future were also proposed.

Key words: synthetic biology, chemicals manufacturing, bioenergy, pharmaceuticals, feedstock, chassis, bioprocess

摘要：

合成生物学即生物学的工程化,因其打破了非生命化学物质和生命物质之间的界线,推动了生命科学由理解生命到创造生命的革新,因此对科学发展和技术创新起到了颠覆性作用,引发了化学品绿色制造的巨大变革。合成生物学作为化学品绿色制造的核心技术,主要从原料到菌种再到过程进行全链条设计和优化。本文首先从原料多样化、产品的合成与底盘细胞的选择这三个方面,综述了化学品绿色制造过程中合成生物学所起到的关键核心作用。在此基础上系统阐述了人工体系的设计与构建,并对今后如何通过发展合成生物学来促进化学品绿色制造,从“原料、底盘细胞、反应过程”这三个方面提出了相应的展望。

关键词: 合成生物学, 化学品制造, 生物能源, 药物, 原料, 底盘细胞, 生物过程

CLC Number:

TQ033

XIAO Wenhai, WANG Ying, YUAN Yingjin. Core technology in chemicals green manufacturing: synthetic biology[J]. CIESC Journal, 2016, 67(1): 119-128.

肖文海, 王颖, 元英进. 化学品绿色制造核心技术——合成生物学[J]. 化工学报, 2016, 67(1): 119-128.

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